ISSN:
1573-6903
Keywords:
Garlic
;
thioallyl group
;
rat hippocampus
;
neuronal survival
;
axonal branching
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Several organosulfur compounds found in garlic extract promoted the survival of rat hippocampal neurons in vitro. From the analysis of structure-activity relationship, thioallyl group in these compounds is essential for the manifestation of neurotrophic activity. S-Allyl-L-cysteine (SAC), one of the organosulfur compounds having thioallyl group in garlic extract, also promoted the axonal branching of cultured neurons. These results suggest that thioallyl compounds make a unique group of neurotrophic factors.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1021946210399
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