Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Interpretation of the potential fields generated in the cerebellar cortex by a mossy fibre volley (1967)
    Springer
    Experimental brain research 3 (1967), S. 58-80 
    Details
    ISSN: 1432-1106
    Keywords: Mossy fibres ; Cerebellar cortex ; Golgi cells ; Granule cells ; Purkinje cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Potential fields and unitary spikes in the cat cerebellar cortex were generated specifically by mossy fibre volleys and recorded by means of microelectrodes. The mossy fibres were excited by trans-folial (T. F.) stimulation which was compared with juxtafastigial (J.F.) stimulation. Both were conditioned by local stimuli of parallel fibres. 2. In the granular layer, an incoming mossy fibre volley evoked a small diphasic potential (P1 N1) and about 0.4 msec later a second negative wave (N2) due to the excitatory synaptic current generated by synapses of mossy fibres with granule cells and Golgi cells. In the typical configuration the N2 wave usually had a superimposed double spike potential, which is due to impulses discharged first by Golgi cells and then, about 0.5 msec later, by granule cells. 3. The transmission of impulses along the perpendicular axons of the granule cells and thence along the parallel fibres gave the fairly sharp positive potential (P2) in the granular layer, and simultaneously the negative wave (N3) in the molecular layer. The parallel fibre impulses, in turn, synaptically excited and so evoked local responses and action potentials in the dendrites of Purkinje and other cells, which aided in the production of the latter part of the N3 wave. 4. The impulses in the Purkinje cell dendrites propagate into the granular layer via the Purkinje cell somata and axons so producing the negative wave (N4) in the Purkinje and the granular layer. 5. The late and prolonged positive wave (P3) may be attributable to the deep active sources produced by postsynaptic inhibition of Purkinje cells and of granule cells by basket and Golgi cells respectively. 6. There has been good correlation between the physiological findings and the anatomical structures of the various types of cells and the synaptic connections, even to the synapses of mossy fibres on Golgi cell dendrites that have been recently described by HÁmori and SzentÁgothai.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00234470
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    A comparison of the inhibitory actions of Golgi cells and of basket cells (1967)
    Springer
    Experimental brain research 3 (1967), S. 81-94 
    Details
    ISSN: 1432-1106
    Keywords: Cerebellar inhibition ; Golgi cells ; Basket cells ; Purkinje cells ; Granule cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. There has been a comparative study of two kinds of inhibition in the cerebellar cortex: basket cell inhibition of Purkinje cells; and Golgi cell inhibition of granule cells. These inhibitory actions were assayed by the degree of inhibition of the potential waves that juxta-fastigial (J.F.) stimulation evoked in the granular or molecular layers: basket cell inhibition by the N1 wave generated by antidromic invasion of Purkinje cells; and Golgi cell inhibition of the N3 or P2 waves evoked by the mossy fibre volley in the molecular and granular layers respectively. 2. The Golgi cell inhibition produced by a parallel fibre volley (LOC stimulation) extended transversely for no more than 200 μ on either side of the narrow beam of the excited parallel fibres, whereas the spread of basket cell inhibition was much larger — to as far as 1 mm. 3. When activated by the on-beam LOC stimulation, the Golgi cell and the basket cell inhibition showed much the same threshold of the stimulation. The off-beam LOC stimulation produced only the basket cell inhibition which is in conformity with the different transverse distributions described in (2) above. 4. When evoked by J. F. or trans-folial (T. F.) stimulation, the Golgi cell inhibition had a much lower threshold than the basket cell inhibition. It is suggested that in part at least this is attributable to the direct synaptic connection from mossy fibres to Golgi cells. 5. The Golgi cell inhibition elicited by the LOC stimulation showed a relatively short time course, the maximum being attained by about 10 msec, after which there was an approximately exponential decrease so that the total duration was only about 100 msec. On the other hand, the basket cell inhibition had a much slower time course, maximum being attained at a latency of 20 to 40 msec, the total duration being even in excess of 200 msec. Suggestions are made with respect to the factors responsible for the slow time course of the basket cell inhibition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00234471
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Afferent volleys in limb nerves influencing impulse discharges in cerebellar cortex I. In mossy fibers and granule cells (1971)
    Springer
    Experimental brain research 13 (1971), S. 15-35 
    Details
    ISSN: 1432-1106
    Keywords: Cerebellum ; Mossy fibers ; Granule cells ; Afferent volleys
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This paper is the first of a series in which the processing of information in the cerebellum has been studied by investigating the effects that known inputs from limb nerves produce on the unitary spike potentials in the cerebellar cortex. These spikes have been recorded extracellularly at all depths along microelectrode tracks in the 5th, 4th and 3rd lobules of the anterior lobe in the lateral vermis or in the pars intermedia. These units have a background frequency of discharge, often very irregular, and computer averaging techniques have been employed in order to derive reliable information on the time course and intensity of the excitatory and/or inhibitory actions produced by the input against this background. Most of the spike responses recorded from the granular layer fall into two classes, one characteristic of impulses in mossy fibers, and the other of impulse discharges from granule cells. Both in the spontaneous background and in the response to afferent volleys in limb nerves the mossy fibers exhibit a performance in close accord with that described for the discharges up the spino-cerebellar tracts. The short latency of 6–9 msec for hindlimb stimuli and the high frequency burst response of 2–4 impulses are characteristic. The mossy fibers displayed a wide variety of responses to the wide range of testing inputs, there being various combinations of excitatory and inhibitory responses and also delayed excitatory actions, all of which must be assumed to be reflections of synaptic influences on the cells of origin of the mossy fibers in the spinal cord. Granule cells have a longer latency by several milliseconds, 9–20 msec for the hindlimb, and a slower frequency in their burst response which tended to be longer and more irregular. The small unitary spike potentials are more difficult to isolate. Also with repetitive stimulation granule cells are more readily depressed than are mossy fibers. Usually a granule cell exhibits a wider range of response to the various cutaneous and muscular afferents of a limb. Both mossy fibers and granule cells may display reciprocal responses to volleys from muscle nerves to antagonistic muscles. This attempt to define properties of the mossy fiber and granule cell spike potentials should help in their identification in future investigations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00236428
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...