ISSN:
1432-0428
Schlagwort(e):
Genetic susceptibility in diabetes
;
Type 1 diabetes
;
the HLA system in diabetes
;
HLA-DW typing
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Summary HLA-D specificities have been investigated in 58 classical Type 1 diabetics and 43 healthy subjects. Both groups were selected according to the HLA-B locus antigens which are known to have a significant positive or negative association with the disease. The results indicate that (1) the primary association of the disease is with HLA-DW3, (2) the increased frequency of DW4 in diabetics with rare exception is co-existent with the presence of DW3, (3) the low frequency of DW2 is secondary to the increase in DW3 and/or DW4, and is not consistent with a primary ‘protective’ role. It is suggested that these data support the hypothesis of interaction between HLA-linked genes operating by separate mechanisms to confer the susceptibility to young onset Type 1 diabetes (Type 1 A).
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF01228300
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