ISSN:
1432-0738
Keywords:
Carbon disulfide
;
Viscose rayon industry
;
CS2-metabolite
;
Biological monitoring
;
2-Thiothiazolidine-4-carboxylic acid
;
HPLC
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract A compound was isolated from the urine of workers exposed to carbon disulfide during the production of rayon. The compound was identified as 2-thiothiazolidine-4-carboxylic acid (TTCA) by GC/MS and NMR. A HPLC method for the quantitative determination of TTCA was elaborated and applied to urine samples. The method allowed detection of TTCA concentrations in urine as low as 5 × 10−7 M. No TTCA was detected in urine of workers occupationally exposed to organic solvents other than CS2. High concentrations of TTCA (upto 32×10−5 M) were shown to be present in urine of spinners exposed to CS2 concentrations of approximately 100 mg/m3. It is suggested that the assay of urinary TTCA is suitable for detection of occupational exposure to CS2.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00297130
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