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  • 1
    Electronic Resource
    Electronic Resource
    Identification, characterization and chromosomal localization of the cognate human and murine DBF4 genes (1999)
    Springer
    Molecular genetics and genomics 262 (1999), S. 220-229 
    Details
    ISSN: 1617-4623
    Keywords: Key words Mammalian Dbf4 ; Cdc7 kinase ; MCM2 ; Initiation of DNA replication ; Cell cycle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The kinase Dbf4p/Cdc7p is required for the G1/S phase transition during the cell cycle and plays a direct role in the activation of individual origins of replication in Saccharomyces cerevisiae. Here, we report the identification and characterization of mouse and human cDNAs whose products are related in sequence to Saccharomyces cerevisiae DBF4 cDNA. Both mammalian Dbf4 proteins contain a putative site for phosphorylation by CDK, PEST protease cleavage sites, nuclear localization signals and a short-looped zinc finger-like domain. Transcription of MmDBF4 is suppressed in mouse NIH3T3 fibroblasts made quiescent by serum starvation. Upon replenishment of the medium, transcript levels increase during progression through G1, peaking as cells enter S phase. MmDbf4p interacts physically with Cdc7p and Mcm2p in vivo. Using fluorescence in situ hybridization (FISH), the human DBF4 gene was localized to chromosome 7 (q21.3), whereas FISH mapped the murine counterpart to band A2 on chromosome 5. The results of chromosome mapping indicate that in both mouse and human the gene is present as a single copy. The structural conservation between Dbf4-related proteins suggests that these proteins play a key role in the regulation of DNA replication during the cell cycle in all eukaryotes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004380051078
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  • 2
    Electronic Resource
    Electronic Resource
    MRI and CT of a haemangioma of the mandible in Kasabach-Merritt syndrome (2000)
    Springer
    Neuroradiology 42 (2000), S. 215-217 
    Details
    ISSN: 1432-1920
    Keywords: Key words Kasabach-Merritt syndrome ; Haemangioendothelioma, kaposiform ; Haemangioma, bone changes ; Disseminated intravascular coagulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Since the description in 1940 of Kasabach-Merritt syndrome (KMS) in patients with capillary haemangiomas, several other vascular tumours have been recognised as possible causes of this coagulopathy. The literature suggests a specific histological pattern of vascular tumours responsible for KMS, excluding capillary haemangioma [1]. There is an extensive literature on, haemangiomas accompanied by thrombocytopenia, and imaging of thrombosis in the lesion, especially cavernous haemangioma of the liver. However, no report has described a haemangioma of the mandible in the acute stage of the coagulopathy, or serial examinations of such a lesion. We report the features of a mandible lesion with KMS and discusses the interpretations of the changes observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050050
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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