ISSN:
1432-0533
Keywords:
High-voltage electron microscopy
;
Horseradish peroxidase
;
Blood-brain barrier
;
Endothelial cell
;
Endothelial cell tubules and channels
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary High-voltage electron microscopy was applied to the study of endothelial cell (EC) transport of macromolecules in a murine model of blood-brain barrier injury to study the role of the EC canalicular system following brain insult. Semithick sections from mouse brains subjected to acute (2–3 h) mechanical trauma demonstrated permeation of intravenously injected horseradish peroxidase via tubular structures either (a) in the absence of lysosome-associated structures in close proximity, or (b) in association with lysosomes, dense bodies or multivesicular bodies. Our data suggest a dual-purposed system of tubules, one portion that supplies the metabolic requirements of the cell and another portion, suggested to be more limited, that opens up as a result of brain injury.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00687249
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