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  • 1
    Electronic Resource
    Electronic Resource
    Comparison of differentiation patterns in 12-O-tetradecanoylphorbol-13-acetate-treated epidermis and fetal epidermis (1985)
    Springer
    Archives of dermatological research 277 (1985), S. 457-465 
    Details
    ISSN: 1432-069X
    Keywords: Epidermis ; Hyperplasia ; TPA ; Stereology ; Morphometry ; Tumor promotors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 12-O-Tetradecanoylphorbol-13-acetate (TPA)-treated adult epidermis as well as untreated fetal and adult epidermis were investigated to elucidate the effect of TPA in terms of cell differentiation using techniques of ultrastructural stereology. Twenty-four hours after a single application of TPA, the treated epidermis was characterized by involutional changes, i. e., increased volume density of intercellular spaces and of mitochondria, vacuoles, and cytoplasmic ground substance in the basal layer. However, 48 h after application, the TPA-treated epidermis was very similar to fetal epidermis, i. e., high volume density of nuclei ribosomes, rough endoplasmic reticulum, membrane-coating granules, and keratohyalin granules, and low volume density of bundled filaments in the upper layers. These stereological data indicate that the changes observed 48 h after TPA treatment were related not only to increased cell proliferation but also to inhibition of cell differentiation expressed as a reversion of the adult differentiation patterns and the acquisition of fetal characteristics in all epidermal layers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00510063
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  • 2
    Electronic Resource
    Electronic Resource
    Contribution of immunophenotypic and genotypic analyses to the diagnosis of acute leukemia (1995)
    Springer
    Annals of hematology 71 (1995), S. 13-27 
    Details
    ISSN: 1432-0584
    Keywords: Acute leukemia ; Diagnosis ; Immunophenotypic ; Cytogenetics ; Molecular genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Diagnostic accuracy in acute leukemia (AL) can be improved if traditional morphology and cytochemistry are supplemented with immunophenotypic and genotypic analyses. This multiparameter approach is of crucial importance for the management of patients, as it enables the identification of leukemic syndromes with distinct biological features and response to treatment. Immunophenotyping using monoclonal antibodies has been universally accepted as a useful adjunct to morphological criteria. This technique is particularly valuable in diagnosing and subclassifying acute lymphoblastic leukemia and is also essential in certain types of acute myeloid leukemia (AML), such as AML with minimal differentiation or acute megakaryoblastic leukemia. Cytogenetic findings can be quite helpful in establishing the correct diagnosis and can add information of prognostic significance. A number of specific chromosomal abnormalities have been recognized that are very closely, and sometimes uniquely, associated with morphologically and clinically distinct subsets of leukemia. An even more basic understanding of normal and malignant hematopoietic cells has begun to evolve as molecular biology begins to unravel gene misprogramming by Southern and Northern blot analysis, the polymerase chain reaction, and fluorescence in situ hybridization. With the extensive use of these techniques it has become apparent that a proportion of leukemias exhibit the biologically relevant molecular defect in the absence of a karyotypic equivalent. On the other hand, apparently uniform chromosomal abnormalities such as the t(1;19) (q23;p13), t(9;22) (q33;q11), t(8;14) (q24;q32), or t(15;17) (q21;q21) may differ at the molecular level. Data collected from these modern technologies have introduced a greater complexity, which needs to be taken into consideration to improve both the diagnostic precision and the reproducibility of current classifications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01696228
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Contribution of immunophenotypic and genotypic analyses to the diagnosis of acute leukemia (1995)
    Springer
    Annals of hematology 71 (1995), S. 13-27 
    Details
    ISSN: 1432-0584
    Keywords: Key words Acute leukemia ; Diagnosis ; Immunophenotypic ; Cytogenetics ; Molecular genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Diagnostic accuracy in acute leukemia (AL) can be improved if traditional morphology and cytochemistry are supplemented with immunophenotypic and genotypic analyses. This multiparameter approach is of crucial importance for the management of patients, as it enables the identification of leukemic syndromes with distinct biological features and response to treatment. Immunophenotyping using monoclonal antibodies has been universally accepted as a useful adjunct to morphological criteria. This technique is particularly valuable in diagnosing and subclassifying acute lymphoblastic leukemia and is also essential in certain types of acute myeloid leukemia (AML), such as AML with minimal differentiation or acute megakaryoblastic leukemia. Cytogenetic findings can be quite helpful in establishing the correct diagnosis and can add information of prognostic significance. A number of specific chromosomal abnormalities have been recognized that are very closely, and sometimes uniquely, associated with morphologically and clinically distinct subsets of leukemia. An even more basic understanding of normal and malignant hematopoietic cells has begun to evolve as molecular biology begins to unravel gene misprogramming by Southern and Northern blot analysis, the polymerase chain reaction, and fluorescence in situ hybridization. With the extensive use of these techniques it has become apparent that a proportion of leukemias exhibit the biologically relevant molecular defect in the absence of a karyotypic equivalent. On the other hand, apparently uniform chromosomal abnormalities such as the t(1;19) (q23;p13), t(9;22) (q33;q11), t(8;14) (q24;q32), or t(15;17) (q21;q21) may differ at the molecular level. Data collected from these modern technologies have introduced a greater complexity, which needs to be taken into consideration to improve both the diagnostic precision and the reproducibility of current classifications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01696228
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Evidence of fibre hyperplasia in human skeletal muscles from healthy young men? (1991)
    Springer
    European journal of applied physiology 62 (1991), S. 301-304 
    Details
    ISSN: 1439-6327
    Keywords: Muscle ; Muscle fibres ; Histocytochemistry ; Hyperplasia ; Handedness
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cross-sections (thickness 10 μm) of whole autopsied left and right anterior tibialis muscles of seven young previously healthy right-handed men (mean age 23 years, range 18–32 years) were prepared for light-microscope enzyme histochemistry. Muscle cross-sectional area and total number of fibres, mean fibre size (indirectly determined) and proportion of the different fibre types (type 1 and type 2 on basis of myofibrillar adenosine triphosphatase characteristics), in each muscle cross-section were determined. The analysis showed that the cross-sectional area of the left muscle was significantly larger (P〈0.05), and the total number of fibres was significantly higher (P〈0.05), than for the corresponding right muscle. There was no significant difference for the mean fibre size or the proportion of the two fibre types. The results imply that long-term asymmetrical low-level daily demands on muscles of the left and the right lower leg in right-handed individuals provide enough stimuli to induce an enlargement of the muscles on the left side, and that this enlargement is due to an increase in the number of muscle fibres (fibre hyperplasia). Calculations based on the data also explain why the underlying process of hyperplasia is difficult, or even impossible, to detect in standard muscle biopsies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00634963
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    On the construction and numerical solution of transmission-line and lumped network models of Maxwell's equations (1980)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 15 (1980), S. 13-30 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: It is sometimes convenient to express a numerical algorithm in terms of a network model. The physical picture given can often help the engineer to visualize the properties of the method. In field problems, a lumped network model corresponds to a space discrete field while a transmission-line model corresponds to a field which is discrete in space and time. In this paper, the relationship is given between the lumped network models and transmission-line network models used in the steady-state solution of Maxwell's equations in two and three space dimensions. The use of dual networks is also discussed. An analysis is given for the velocity of waves travelling in any direction across the networks and this is used to compare the accuracy of the models. The use of diakoptics or substructures for the solution of large networks is outlined and this is illustrated by a compound two-dimensional example.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620150103
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  • 6
    Electronic Resource
    Electronic Resource
    Turbulent heat transfer via the F.E.M.: Heat transfer in rod bundles (1983)
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 3 (1983), S. 363-375 
    Details
    ISSN: 0271-2091
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Heat transfer associated with forced convection between bundles of cylindrical fuel rods is analysed using the finite element method. A subchannel technique is employed and the numerical results are compared with previous experimental and numerical values. The solid and fluid zones are analysed, for temperature distribution, as a single domain.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/fld.1650030406
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  • 7
    Electronic Resource
    Electronic Resource
    Editorial (1994)
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 19 (1994), S. iii 
    Details
    ISSN: 0271-2091
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/fld.1650190702
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Editorial (1994)
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 19 (1994), S. i 
    Details
    ISSN: 0271-2091
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/fld.1650190810
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Editorial (1994)
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 19 (1994), S. i 
    Details
    ISSN: 0271-2091
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/fld.1650190910
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Editorial (1994)
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 19 (1994), S. i 
    Details
    ISSN: 0271-2091
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/fld.1650191008
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    Paper (German National Licenses)
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