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  • 1995-1999  (5)
  • Visual evoked potentials  (3)
  • INFLAMMATORY BOWEL DISEASE  (2)
  • 1
    ISSN: 1432-1920
    Schlagwort(e): Key words Magnetic resonance imaging ; Optic neuritis ; Multiple sclerosis ; Visual evoked potentials
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract MRI of the optic nerves was obtained in 13 patients with acute optic neuritis and 13 with a previous optic neuritis (ON), assessed by clinical features, visual fields and visual evoked potentials. Results of the conventional short tau inversion recovery (STIR) sequence obtained with a short echo time (STE-STIR; 22 ms) were compared with those of a long echo time (LTE-STIR: 80 ms) sequence. The conventional STE-STIR sequence revealed lesions in the optic nerves in 78.5 % of acute and 58.8 % of previous ON. The LTE-STIR sequence showed abnormalities in 92.8 % of acutely symptomatic nerves and 94.1 % of nerves with previous ON. The optic nerve lesions appeared significantly longer with the LTE-STIR sequence than with the conventional STE-STIR sequences, in both acute and previous ON.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    ISSN: 1432-1920
    Schlagwort(e): Magnetic resonance imaging ; Optic neuritis ; Multiple sclerosis ; Visual evoked potentials
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract MRI of the optic nerves was obtained in 13 patients with acute optic neuritis and 13 with a previous optic neuritis (ON), assessed by clinical features, visual fields and visual evoked potentials. Results of the conventional short tau inversion recovery (STIR) sequence obtained with a short echo time (STE-STIR; 22 ms) were compared with those of a long echo time (LTE-STIR: 80 ms) sequence. The conventional STE-STIR sequence revealed lesions in the optic nerves in 78.5% of acute and 58.8% of previous ON. The LTE-STIR sequence showed abnormalities in 92.8% of acutely symptomatic nerves and 94.1% of nerves with previous ON. The optic nerve lesions appeared significantly longer with the LTE-STIR sequence than with the conventional STE-STIR sequences, in both acute and previous ON.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    ISSN: 1590-3478
    Schlagwort(e): Visual evoked potentials ; VEP ; Optic neuritis ; Multiple sclerosis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Sommario I 20 pazienti affetti da Neurite Ottica (NO), descritti nel precedente lavoro [23] sono stati sottoposti a registrazioni seriali multicanali dei Potenziali Evocati Visivi (PEV), per un periodo di 2 anni dall'esordio della NO. I PEV potevano correlare con le lesioni evidenziate con la Risonanza Magnetica, con le alterazioni campimetriche e con altri reperti clinici. Basandoci sulla loro distribuzione in mappa, i PEV sono stati classificati come realmente “ritardati” e “pseudo-ritardati”. PEV realmente “ritardati” potevano essere registrati all'esordio, o precocemente dopo l'episodio di NO, e la presenza del “ritardo” stava ad indicare un recupero della funzione visiva e, quindi, una prognosi fausta. Gli “pseudo-ritardi” indicavano un'alterazione del campo visivo a prognosi non favorevole per un recupero della funzione visiva, a meno che entro i primi 3 mesi dalla NO si fosse verificata una ricomparsa di componenti normali o “ritardate”. Gli “pseudo-ritardi” erano rilievi caratteristici nei pazienti con lesioni maggiormente lunghe alle immagini LTE-STIR MRI [23]. Nessuna correlazione è stata trovata tra latenza dei PEV e lunghezza delle placche. I nostri rilievi sono in disaccordo con precedenti teorie relative ai tempi di instaurazione-recupero delle alterazioni di conduzione nella NO e nella Sclerosi Multipla.
    Notizen: Abstract Twenty patients with optic neuritis (ON) described in the previous study [23] underwent serial VEP recordings (using multiple electrode arrays) for two years. The VEPs could be correlated with the lesions revealed by MRI, Visual Field tests and other clinical findings. On the basis of their scalp distribution, they were classified as “really delayed” VEPs and “pseudo-delayed” VEPs. Real delays could be recorded at the onset of ON or shortly afterwards, and their appearance indicated the recovery of visual function and a good prognosis. Pseudo-delays indicated an alteration in the visual field and, unless a breakthrough of normal or delayed components appeared in the first three months, following acute ON, indicate a poor prognosis for the recovery of visual function. The pseudo-delayed VEPs were mainly observed in patients with longer lesions revealed by means of LTE-STIR MRI [23]; there was no correlation between VEP latency and the length of plaques. Our findings contradict previous theories on the timing of conduction alterations in ON and multiple sclerosis.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Springer
    Digestive diseases and sciences 43 (1998), S. 1356-1361 
    ISSN: 1573-2568
    Schlagwort(e): INFLAMMATORY BOWEL DISEASE ; THROMBOPHILIA ; COAGULATION ; ACTIVATED PROTEIN C ; RESISTANCE
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Thromboembolic events frequently complicate theclinical course of patients with inflammatory boweldisease (IBD). Hereditary thrombophilia may contributeto this tendency. Resistance to activated protein C is the most recently described thrombophilicstate and may account for up to 40% of patients withthrombophilia. Thirty-seven patients with IBD werestudied (mean age 44 years, range 18-82 years). Three patients had a history of thrombotic episodes.The 37 controls included 23 men and 17 women (mean age48 years, range 16-89 years). Disease activity wasassessed using the Harvey Bradshaw index for patients with Crohn's disease and the Truelove and Wittsgrading system for patients with ulcerative colitis.Levels of fibrinogen, antithrombin III (ATIII), proteinC, protein S, activated protein C resistance (APCR), and the presence of a lupusanticoagulant (LA) were determined. Median ATIII levelsin patients with IBD were significantly lower thancontrols (98% vs 106%, P = 0.007), while fibrinogen waselevated (4.2 vs 3.3 g/liter, P = 0.026) despitequiescent disease activity. LA was detected in 7/37patients in the IBD group compared to 0/37 controls.(χ2 = 5.68, P = 0.017). No significantdifference was observed in levels of inherited thrombophilic factorsand in particular APCR between IBD patients andcontrols. In conclusion, the presence of inheritedthrombophilic defects, in particular APCR, is uncommonin patients with IBD and does not merit routinescreening.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 5
    ISSN: 1573-2568
    Schlagwort(e): INFLAMMATORY BOWEL DISEASE ; ANTI-CARDIOLIPIN ANTIBODIES ; DEEP VENOUS THROMBOSIS
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Elevated levels of anti-cardiolipin antibodiesare associated with an increased risk for venous andarterial thrombosis. In patients with inflammatory boweldisease thrombosis is a well known complication. We determined the prevalence of elevatedanti-cardiolipin antibodies in 136 patients withinflammatory bowel disease compared with 136 healthycontrols and analyzed thromboembolic complications inpatients with increased anti-cardiolipin antibodylevels. Anti-cardiolipin antibody titers weresignificantly elevated in patients with Crohn's disease(5.7 units/ml) and ulcerative colitis (5.3 units/ml)compared to the control group (2.5 units/ml). We foundno correlation between disease activity andanti-cardiolipin antibody levels. Seven patients haddeep venous thrombosis in their history, in three ofthem this was complicated by pulmonary embolism. In onlytwo of the seven patients with deep venous thrombosiswere anti-cardiolipin antibody levels increased. Inconclusion, anti-cardiolipin antibody titers were significantly increased in patients withinflammatory bowel disease. Elevated anti-cardiolipinantibody levels appear to play no role in thepathogenesis of thromboembolic events in patients withinflammatory bowel disease.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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