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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 65 (1987), S. 773-780 
    ISSN: 1432-1440
    Keywords: Streptococci ; Septicemia ; Acute leukemia ; High dose cytosine arabinoside
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty-nine adult patients with acute myelogenous leukemia AML who received 40 treatment courses with high dose cytosine arabinoside (HD-A), alone or combined with other cytotoxic drugs, for remission induction (RI) or postremission intensive consolidation (IC) were retrospectively analysed for types and severity of infectious complications. In this paper, we report the unusually high rate of streptococcal septicemia in our patients. Of 13 bacteremic infections in a total of 45 infectious episodes, 10 were caused by streptococci (9 viridans streptococci, 1 group B hemolytic streptococcus). Three of them were lethal. After reviewing all documented cases of streptococcal septicemia in the same study period, four additional cases among adult patients with AML were identified. Three of them have had antileukemic chemotherapy without HD-A, while one have had HD-A as a conditioning regimen for bone marrow transplantation. Only three cases were documented to occur in adult patients with AML. Patients treated with HD-A for RI or IC had a significantly lower risk of streptococcal septicemia during previous chemotherapy-associated febrile neutropenic episodes (1/55 vs 10/45;P=0.01). Neither prophylactic regimens including trimethoprim-sulfamethoxazole nor those without it were effective in preventing streptococcal septicemia. Further studies are needed to confirm these data before the value of additional or alternative prophylactic antibiotics is proven necessary.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0584
    Keywords: akute LeukÄmie ; Infektionsprophylaxe ; antimikrobielle ; Dekontamination ; reverse Isolation ; Remissionsraten ; Acute leukemia ; Prevention of infection ; Antimicrobial decontamination ; Reverse isolation ; Remission rates
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The efficiency of strict reverse isolation and antimicrobial decontamination in remission induction therapy of acute leukemia was studied retrospectively in 47 patients who were treated with a standardized aggressive chemotherapy of daunorubicin and cytosine arabinoside. Twenty-two patients were treated in strict reverse isolation with antimicrobial decontamination and 25 patients in the open ward without any measures against infections. In the patients in isolation the incidence of new infections per patient was 0.77 compared to 1.42 in the control group. The rate of complete remissions was 77% in the patients in isolation vs. 56 % in the control patients.
    Notes: Zusammenfassung Die Wirksamkeit von strikter reverser Isolation und antimikrobieller Dekontamination bei der Induktionstherapie der akuten LeukÄmie wurde retrospektiv bei 47 Patienten untersucht. Alle Patienten erhielten eine standardisierte aggressive Chemotherapie mit Daunorubicin und Cytosin-Arabinosid. Zweiundzwanzig Patienten wurden in strikter reverser Isolation mit antimikrobieller Dekontamination behandelt, 25 Patienten auf normalen Krankenstationen ohne Ma\nahmen zur Infektionsprophylaxe. Die HÄufigkeit neuer Infektionen pro Patient war 0,77 bei den isolierten Patienten und 1,42 in der Kontrollgruppe. Die Rate kompletter Remissionen betrug bei den isolierten Patienten 77% im Vergleich zu 56% bei den Patienten auf den normalen Krankenstationen.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1440
    Keywords: Pyelonephritis ; Antibody-coated-bacteria ; Subcultures ; Immunofluorescence test ; Urinary immunoglobulins ; Bakterielle Nephritis ; Antikörperbesetzte Bakterien ; Subkulturen ; Immunfluoreszenztest ; Immunglobuline im Urin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurden drei Kollektive a) mit sterilem Urin b) mit signifikanter Bakteriurie ohne Antikörperbesatz c) mit signifikanter Bakteriurie mit Antikörperbesatz erstellt. Mittels Partigenplatten wurde im Urin quantitativ IgG, IgA, IgM und Transferrin bestimmt. Der Antikörperbesatz auf der Bakterienzellwand wurde mit dem Immunfluoreszenztest nachgewiesen. Von den bakterienhaltigen Urinen wurden Subkulturen angelegt. Die Subkulturkeime wurden mit dem ursprünglichen, jedoch mittels Bakterienfilter keimfrei gemachten Urin inkubiert und anschließend mit fluorescein-konjugiertem AH-IgG behandelt. Von mehreren Patienten konnte Serum gewonnen werden, mit welchem die Subkulturkeime ebenfalls inkubiert und anschließend mit fluorescein-konjugiertem AH-IgG behandelt wurden. Es konnte gezeigt werden, daß in keinem Falle im Urin spezifische Antikörper gegen die infizierenden Organismen vorhanden waren, obgleich die IgG-Menge im Urin erhöht und im Serum spezifische Antikörper nachgewiesen werden konnten. Dies erlaubt den Schluß, daß die Induktion zur spezifischen Antikörperbildung durch direkten Gewebekontakt der Mikroorganismen erfolgt und die Bakterien im Interstitium und nicht im Urin mit Antikörpern besetzt werden.
    Notes: Summary Three groups of subjects have been studied: the first group with sterile urine, the second with significant bacteriuria without antibody-coated bacteria and the third with significant bacteriuria with antibody-coated bacteria. IgG, IgA, IgM and transferrin were determined by immunological methods (partigen plates). The antibody coating was determined by immunofluorescence. Subcultures were prepared from the urine samples containing bacteria. The bacteria obtained from the subcultures were then incubated with the original urine which had been sterilised by passing through a filter. These were then treated with AH-IgG containing fluorescein. Serum was taken from several patients and incubated with the bacteria from the subcultures. These were also treated with AH-IgG fluorescein. In no case could specific antibodies against the infecting organisms be found, although IgG in the urine were elevated and specific antibodies were present in the serum. This leads to the conclusion that specific antibodies are formed by direct tissue contact of the bacteria and that coating is not established in the urine itself.
    Type of Medium: Electronic Resource
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