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  • 1
    Electronic Resource
    Electronic Resource
    ESR of pyro-graphite irradiated by ions-II. High energy ion bombardments
    Amsterdam : Elsevier
    Journal of Physics and Chemistry of Solids 47 (1986), S. 633-645 
    Details
    ISSN: 0022-3697
    Keywords: ESR ; Graphite ; annealing ; defects ; high energy ions ; hopping motion ; irradiation ; metal-nonmetal transition
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-3697(86)90167-8
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    ESR of pyro-graphite irradiated by ions-I. Low energy ion bombardments
    Amsterdam : Elsevier
    Journal of Physics and Chemistry of Solids 47 (1986), S. 617-631 
    Details
    ISSN: 0022-3697
    Keywords: ESR ; Graphite ; Raman ; annealing ; defects ; irradiation ; low energy ions ; metal-nonmetal transition
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-3697(86)90166-6
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Imunohistochemical demonstration of langerhans' cell in cholesteatoma using an antiserum against S-100 protein (1989)
    Springer
    European archives of oto-rhino-laryngology and head & neck 246 (1989), S. 48-52 
    Details
    ISSN: 1434-4726
    Keywords: Cholesteatoma ; Langerhans' cell ; S-100 protein ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The epidermal Langerhans' cells play an important role in immunological reactions resulting from chronic inflammations of the skin. Recently, S-100 protein, one of the nervous-system-specific proteins, has been shown to be a useful marker for the epidermal Langerhans' cells. We investigated the localization of Langerhans' cells in human cholesteatoma specimens by means of an immunohistochemical method for detecting S-100 protein. A large number of Langerhans' cells containing S-100 protein immunoreactivity were found in the epithelium of the cholesteatoma and also in the subepithelial region. This immunoreactivity was detected both in the cytoplasm of the Langerhans' cells and their dendritic processes along their entire lengths. The number of S-100 positive Langerhans' cells in cholesteatoma associated with otorrhea increased significantly as compared with normal epithelium from the external auditory canal and tympanic membrane, while no increase in the number of S-100-positive cells was recognized in cholesteatoma without otorrhea. The S-100-positive dendritic cells in the cholesteatoma revealed longer and more complexly branched processes than those in normal tissues. These findings suggest that the Langerhans' cells within the cholesteatomatous lesion are responsible for generating and maintaining the chronic immunological reactions in this disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00454134
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Expressions of a calcium-binding protein (spot35/calbind in-D28k) in mouse olfactory cells: Possible relationship to neuronal differentiation (1997)
    Springer
    European archives of oto-rhino-laryngology and head & neck 254 (1997), S. 105-109 
    Details
    ISSN: 1434-4726
    Keywords: Immunohistochemistry ; Olfactory epithelium ; Cell growth ; Proliferating cell nuclear antigen ; Olfaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We used immunohistochemistry to investigate the expression of spot35/calbindin-D28k (calbindin) in mouse olfactory epithelium during development. Cell stages of immunopositive olfactory cells were determined by comparing the levels of proliferating cell nuclear antigen (PCNA). Calbindin-positive cells were abundant in the middle layer of the epithelium of animals before 2 weeks of age and gradually diminished during development. Only low levels were detectable near the basement membrane in the adult. Changes of calbindin-positive cells in terms of number and distribution were apparently compatible with localization changes of premature olfactory cells. PCNA overlapped calbindin in the nasal mucosa at lower magnifications on stained serial sections and immunohistochemical double staining revealed that calbindin-mmunoreactive cells were located mainly just above PCNA-immunoreactive cells in the basal layer of the epithelium. This indicated that calbindin is expressed postmitotically in immatureolfactory cells and is lost by mature cells. These findings suggest that calbindin might support the maturation of the olfactory cells, such as the projection of the neuronal processes, by stabilizing intracellular calcium ions in immature cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01526190
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  • 5
    Electronic Resource
    Electronic Resource
    Importance of type IV collagen, laminin, and heparan sulfate proteoglycan in the regulation of labyrinthine fluid in the rat cochlear duct (1998)
    Springer
    European archives of oto-rhino-laryngology and head & neck 255 (1998), S. 285-288 
    Details
    ISSN: 1434-4726
    Keywords: Key words Cochlear duct ; Basement membrane ; Immunohistochemistry ; Fluid transport
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The distribution of major components of the basement membrane, such as type IV collagen, laminin, and heparan sulfate proteoglycan (HSPG), was investigated in the rat cochlear duct. Immunofluorescence demonstrated that type IV collagen, laminin and HSPG were distributed along capillaries in the cochlear duct, including the stria vascularis, spiral ligament, spiral prominence and spiral limbus. Additionally, type IV collagen, laminin and HSPG were found to be distributed from the basement membrane of Reissner’s membrane to that of the spiral prominence in a linear pattern. The scala media was surrounded by these basement membrane components, demarcating endolymph from perilymph, along epithelial cells except at the stria vascularis. These findings suggest that type IV collagen, laminin and HSPG create the anatomical separation between endolymph and perilymph, thus indicating that they may be involved in the regulation of fluid transport between the endolymph and perilymph.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004050050060
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  • 6
    Electronic Resource
    Electronic Resource
    A re-evaluation of the classification of olfactory epithelia in patients with olfactory disorders (1992)
    Springer
    European archives of oto-rhino-laryngology and head & neck 249 (1992), S. 393-399 
    Details
    ISSN: 1434-4726
    Keywords: Olfactory epithelia ; Olfactory disorder ; Immunohistochemistry ; Classification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have previously demonstrated that human olfactory epithelia can be classified into five grades according to the degree of degeneration present in patients with various kinds of olfactory disorders. In practice, however, the occurrence of additional types of cell changes in other kinds of olfactory disorders and findings with immunohistochemical techniques have led us to re-evaluate our previous classification. In the present study, changes in olfactory epithelia from ten patients with various kinds of olfactory disorders are discussed and a revised classification is proposed. Microvillar and differentiating cells were also evaluated in the epithelium studied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00192261
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  • 7
    Electronic Resource
    Electronic Resource
    Olfactory disturbances caused by the anti-cancer drug tegafur (1995)
    Springer
    European archives of oto-rhino-laryngology and head & neck 252 (1995), S. 48-52 
    Details
    ISSN: 1434-4726
    Keywords: Tegafur ; Bromodeoxyuridine ; Proliferating cell nuclear antigen ; Immunohistochemistry ; Cell mitoses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Olfactory disturbances induced by the anticancer drug tegafur were studied in separate clinical and experimental investigations. Five patients with olfactory dysfunction after tegafur were studied and were found to have normal endoscopic findings of the olfactory cleft mucosa. The average period for drug administration was 22 months. Recovery from the olfactory disturbance was poor and biopsy of the olfactory mucosa revealed severely degenerated epithelium. In experimental studies in a guinea pig animal model, effects of oral tegafur on mitotic cells in the olfactory epithelium were examined using bromodeoxyuridine (BrdU) uptake as index. At the conclusion of 3 weeks' treatment, no pronounced morphological changes were seen, but the number of BrdU-incorporating cells decreased in proportion to the dose of tegafur used. Following long-term administration of tegafur 18 months, mitotic cells reacting to BrdU or proliferating cell nuclear antigen had virtually disappeared, indicating persistent inhibition of mitotic cell activity. Morphological changes present included decreased olfactory cell numbers, loss of cells in areas just above basal cells and degeneration of the mucous layer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00171440
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