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  • 1
    ISSN: 1432-0584
    Keywords: Immunophenotype ; L-CFU Clonogenic leukemic cell ; Acute myeloid leukemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The membrane phenotype of AML clonogenic cells (L-CFU) was analyzed in 19 AML patients using an in vitro culture technique after a complement-mediated lysis assay employing a panel of six monoclonal antibodies (McAb) -HLA-DR, FMC56 (CD9), FMC27 (CD9), CD14, CD15, CD41a-. Our results show that L-CFU has a heterogeneous but immature phenotype lacking on the expression of differentiation antigens (CD14, CD15, CD41a). In addition, we observed that the L-CFU phenotype is different from that of the whole blast cell population. Interestingly, L-CFU showed a higher expression of HLA-DR antigens with respect to their progeny. Upon analyzing whether the L-CFU phenotype was related to both the morphological and immunological features of AML blast cells, it was observed that, while there is no correlation with the FAB classification, there was a partial relationship between the immunological phenotype of AML blast cells and that of L-CFU. Accordingly, the more immature AML cases showed a more differentiated L-CFU phenotype (HLA-DR+, CD9+, FMC27+) when compared with cases with a more mature blast cell phenotype. These results suggest that those AML cases with a relatively immature myeloblastic phenotype may arise from a progenitor cell that has undergone partial differentiation and that is unable to acquire myeloid differentiation antigens, while those AML cases with mature blast cells might emerge from a very early L-CFU that has the capacity to undergo a greater degree of differentiation.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 39 (1996), S. 3175-3194 
    ISSN: 0029-5981
    Keywords: equilibrium elements ; spurious kinematic modes ; macro-elements ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: This paper illustrates a method whereby a family of robust equilibrium elements can be formulated in a general manner. The effects of spurious kinematic modes, present to some extent in all primitive equilibrium elements, are eliminated by judicious assembly into macro-equilibrium elements. These macroelements are formulated with sufficient generality so as to retain the polynomial degree of the stress field as a variable. Such a family of macro-elements is a new development, and results for polynomials of degree greater than two have not been seen before. The quality of results for macro-equilibrium elements with varying degrees of polynomial is demonstrated by numerical examples.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    Communications in Numerical Methods in Engineering 13 (1997), S. 541-552 
    ISSN: 1069-8299
    Keywords: hybrid-equilibrium finite elements ; statically admissible stress fields ; spurious kinematic modes ; self-stressing modes ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The paper describes an unexpected type of convergence behaviour occurring for a single, variable degree, primitive-type equilibrium element. For this element the number of independent stress fields is less than the number of independent boundary displacement variables that do not correspond to rigid element modes of displacement. This leads to the conclusion that the element is hypostatic and that, in the absence of self-stressing modes, no convergence can occur. Such ‘conventional’ counting procedures do not, however, reveal the whole picture, and numerical determination of the rank of the coefficient matrix of the equilibrium equations shows that, in practice, self-stressing modes can and do exist in a model which would conventionally be described as hypostatic. The rank deficiency in the coefficient matrix is shown to be due to the fact that, upon transformation, independent stress fields do not necessarily lead to independent boundary tractions. Generalization to conventionally iso- and hyperstatic models demonstrates that, whenever the coefficient matrix is rank-deficient, spurious kinematic modes coexist with self-stressing modes. The problem which reveals the curious convergence characteristics for the primitive-type element is resolved using a macro-type element, and it is seen that, with the larger degree of hyperstaticity available to this element, strictly monotonic convergence characteristics are observed. © 1997 John Wiley & Sons, Ltd.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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