ISSN:
1432-0428
Keywords:
Impaired glucose tolerance
;
Type 2 diabetes
;
worsening to diabetes
;
multivariate analysis
;
diminished insulin response
;
obesity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In a 5–12 year follow-up study of 288 subjects with impaired glucose tolerance after a 100-g glucose load, 48 worsened to overt Type 2 (non-insulin-dependent) diabetes with the elevation of fasting blood glucose. The initial level of blood glucose was a major predictor of subsequent worsening to diabetes. In addition, subjects with a lower insulin response to glucose showed a higher incidence of worsening to the disease, irrespective of blood glucose levels. Multivariate analysis indicated that a diminished insulin response and a high maximal body weight index, as well as a high level of fasting and 2-h glucose values at the initial 100-g oral glucose tolerance test were significant independent risk factors for the development of diabetes in Japanese subjects.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00252262
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