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  • Artikel: DFG Deutsche Nationallizenzen  (29)
  • Polymer and Materials Science  (17)
  • Inorganic Chemistry  (10)
  • Chronic antidepressant  (2)
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  • Artikel: DFG Deutsche Nationallizenzen  (29)
Materialart
Schlagwörter
  • 1
    ISSN: 1432-1912
    Schlagwort(e): Key words Microdialysis ; 5-HT release ; Chronic antidepressant ; Citalopram ; 5-HT reuptake inhibitor ; Tolerance ; Autoreceptors ; Frontal cortex ; Dorsal hippocampus
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  Rats were administered the selective serotonin (5-HT) uptake blocker citalopram or saline for 14 days to determine if prolonged treatment would lead to changes in extracellular 5-HT or autoreceptor sensitivity. One day after drug withdrawal, dialysis probes were implanted in the frontal cortex and dorsal hippocampus. Dialysis experiments were carried out using chloral hydrate anesthetized rats. The experimental protocol comprised the administration of three consecutive drug challenges: (1) After stable baseline levels were obtained, citalopram was infused through the dialysis probes to locally block uptake in the forebrain. (2) Subsequently, a 5-HT1B receptor agonist (RU24969 or CP93,129) was infused through the probe to test for changes in terminal autoreceptor sensitivity. (3) Last, citalopram was administered systemically to test the effect of indirect activation of somatodendritic autoreceptors. Under these conditions, with uptake already blocked locally in the forebrain, systemic citalopram produces a decrease in extracellular 5-HT, an effect that can be inhibited by pretreatment with antagonists of 5-HT1A receptors. The results indicate that during local infusion of citalopram extracellular 5-HT was significantly higher in the dorsal hippocampus of the chronic citalopram as compared to saline treatment group. This difference persisted throughout the full time course of the experiment. However, the decreases in 5-HT levels produced by local infusion of a 5-HT1B receptor agonist or after systemic citalopram administration were not significantly different between the chronic citalopram and saline treated groups. There were no significant differences between chronic citalopram and saline treated animals in frontal cortex. These results suggest that prolonged inhibition of 5-HT uptake may produce a selective change in the regulation of release from median raphe 5-HT neurons, but this change could not be clearly linked to a change in nerve terminal or somatodendritic autoreceptor sensitivity.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    ISSN: 1432-1912
    Schlagwort(e): Microdialysis ; 5-HT release ; Chronic antidepressant ; Citalopram ; 5-HT reuptake inhibitor ; Tolerance ; Autoreceptors ; Frontal cortex Dorsal hippocampus
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Rats were administered the selective serotonin (5-HT) uptake blocker citalopram or saline for 14 days to determine if prolonged treatment would lead to changes in extracellular 5-HT or autoreceptor sensitivity. One day after drug withdrawal, dialysis probes were implanted in the frontal cortex and dorsal hippocampus. Dialysis experiments were carried out using chloral hydrate anesthetized rats. The experimental protocol comprised the administration of three consecutive drug challenges: (1) After stable baseline levels were obtained, citalopram was infused through the dialysis probes to locally block uptake in the forebrain. (2) Subsequently, a 5-HT1B receptor agonist (RU24969 or CP93,129) was infused through the probe to test for changes in terminal autoreceptor sensitivity. (3) Last, citalopram was administered systemically to test the effect of indirect activation of somatodendritic autoreceptors. Under these conditions, with uptake already blocked locally in the forebrain, systemic citalopram produces a decrease in extracellular 5-HT, an effect that can be inhibited by pretreatment with antagonists of 5-HT1A receptors. The results indicate that during local infusion of citalopram extracellular 5-HT was significantly higher in the dorsal hippocampus of the chronic citalopram as compared to saline treatment group. This difference persisted throughout the full time course of the experiment. However, the decreases in 5-HT levels produced by local infusion of a 5-HT1B receptor agonist or after systemic citalopram administration were not significantly different between the chronic citalopram and saline treated groups. There were no significant differences between chronic citalopram and saline treated animals in frontal cortex. These results suggest that prolonged inhibition of 5-HT uptake may produce a selective change in the regulation of release from median raphe 5-HT neurons, but this change could not be clearly linked to a change in nerve terminal or somatodendritic autoreceptor sensitivity.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    ISSN: 0025-116X
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Physik
    Notizen: 1,3,5-Trioxane (1) and 1,3-dioxep-5-ene (2) were copolymerized with BF3OEt2 at 65°C. The products, after base hydrolysis, were characterized by 13C and 1H NMR and were found to assume the chemical structure 4 of a copolymer containing oxymethylene and oxy-2-butenylene units with 4-hydroxy-2-butenyl and methoxy end groups, with the ratio of hydroxy-2-butenylene to methoxy end groups varying with experimental conditions. The copolymer demonstrates crystallinity and thermal stability comparable to poly(trioxane-co-ethylene oxide)s. Copolymer melting point was observed to decrease with increasing comonomer incorporation. The upper limit for incorporation of the comonomer 2 was found to be ca. 4 mol per cent. Viscosity and end group analysis (by 1H NMR) indicate molecular weights in the range of 104 to 105. The comonomeric unit demonstrates the ability to act as both a stopper against unzipping and as a trap for certain degrading agents.
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 28 (1901), S. 1-44 
    ISSN: 0863-1778
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Zusätzliches Material: 14 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 37 (1903), S. 353-377 
    ISSN: 0863-1778
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Zusätzliches Material: 10 Tab.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 6
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 126 (1923), S. 54-54 
    ISSN: 0863-1786
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: No abstract.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 7
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 147 (1925), S. 68-80 
    ISSN: 0863-1786
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: 1. Fällt man verdünnte, mit Essigsäure schwach angesäuerte Lösungen der Alkalisalze von Citronen-, Bernstein-, Äpfel-, Wein- und Benzoesäure mit verdünnter Bleiacetatlösung, so bilden sich, unabhängig davon, welche der beiden Komponenten im Überschuß angewendet wird, durchweg Niederschläge der neutralen Bleisalze von normaler Zusammensetzung.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 8
    Digitale Medien
    Digitale Medien
    Weinheim [u.a.] : Wiley-Blackwell
    Materials and Corrosion/Werkstoffe und Korrosion 2 (1951), S. 365-367 
    ISSN: 0947-5117
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Maschinenbau
    Beschreibung / Inhaltsverzeichnis: Phase boundary-lines, especially in their impotance for corrosionTwo phases have a common cleavageplane, whilst three phases touch one another along a boundary line only. Corroesponding to an adsorption in the first case in an adlineation in the second case. Both processes diminish the free energy and herewith the activity of the boundary, so inhibiting the possibilities of corrosion.Local elements, glow cathodes and catalysts consisting of several components are typical systems acting at microscopic boundary-lines. Cavitation is the inverse phenomenon.Macroscopic boundary-lines in partially filled containers, formed by wall, liquor and gaseous phase, are about this especially active, as being mixed with a four-phases-point-system, that results from the heterogeneity of the container wall. Gravity potentials, and electrokinetic potentials have their maximum value in the boundary-lines too.
    Notizen: Zwei Phasen haben eine gemeinsame Grenzfläche, während drei Phasen sich nur entlang einer Grenzlinie berühren. Der Adsorption im ersten Falle entspricht eine Adlineation im zweiten Falle. Beide Vorgänge setzen die freie Energie und damit die Aktivität der Grenze herab, hemmen also Korrosionsmöglichkeiten.Lokalelemente, Glühkathoden und Mehrstoff-Katalysatoren sind typische Systeme, die an mikroskopischen Grenzlinien zur Wirkung kommen. Kavitation bildet die inverse Erscheinung hierzu.Makroskopische Grenzlinien an teilgefüllten Behältern, die durch Wandung, flüssigem Inhalt und gasförmiger Phasegebildet werden, sind darüber hinaus besonders aktiv, da sie von einem Vierphasen-Punktsystem durchsetzt sind, das infolge er heterogenität der Behälterwand resultiert.Gravitationspotentiale und elektrokinetische Potentiale haben ebenfalls in den begrenzenden Linien ihren maximalen Wert.
    Materialart: Digitale Medien
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  • 9
    Digitale Medien
    Digitale Medien
    Weinheim [u.a.] : Wiley-Blackwell
    Materials and Corrosion/Werkstoffe und Korrosion 5 (1954), S. 359-359 
    ISSN: 0947-5117
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Maschinenbau
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 10
    Digitale Medien
    Digitale Medien
    Weinheim [u.a.] : Wiley-Blackwell
    Materials and Corrosion/Werkstoffe und Korrosion 15 (1964), S. 700-701 
    ISSN: 0947-5117
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Maschinenbau
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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