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  • Computational Chemistry and Molecular Modeling  (4)
  • Inward rectifying potassium channel  (2)
  • 1
    Digitale Medien
    Digitale Medien
    Serotonin and protein kinase C modulation of a rat brain inwardly rectifying K+ channel expressed inXenopus oocytes (1996)
    Springer
    Pflügers Archiv 431 (1996), S. 335-340 
    Details
    ISSN: 1432-2013
    Schlagwort(e): Serotonin ; Inward rectifying potassium channel ; Brain ; PKC ; 5-HT2C receptor ; Heterologous expression ; Xenopus laevis oocytes ; Modulation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract InXenopus laevis oocytes injected with rat brain poly(A)+ RNA, perfusion with a high-K+ solution (96 mM KCl) generated an inward current (I HK) which was absent in water-injected oocytes. Part ofI HK was blocked by low concentrations of Ba2+ (half-maximal inhibitory concentration, IC50: 4.2 ± 0.5 μM). When serotonin (5-HT) was applied to these oocytes a transient inward oscillating Cl− current arising from activation of Ca2+ -dependent Cl− channels,I Cl(Ca), was observed. When this response decayed, a 30% reduction ofI HK could be detected. Electrophysiological characterization of the K+ channel down-modulated by 5-HT revealed that it is an inward rectifier. Antisense suppression experiments revealed that the 5-HT2C receptor mediates the down-modulatory effect of 5-HT. The nature of the modulatory pathway was investigated by application of phorbol esters and intracellular injection of protein kinase C (PKC) inhibitors, ethylenebis (oxonitrilo)tetraacetate (EGTA) and inositol 1, 4, 5-trisphosphate. The results demonstrate that PKC is responsible for the down-modulatory effect.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02207270
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  • 2
    Digitale Medien
    Digitale Medien
    Serotonin and protein kinase C modulation of a rat brain inwardly rectifying K+ channel expressed in Xenopus oocytes (1996)
    Springer
    Pflügers Archiv 431 (1996), S. 335-340 
    Details
    ISSN: 1432-2013
    Schlagwort(e): Key words Serotonin ; Inward rectifying potassium channel ; Brain ; PKC ; 5-HT2C receptor ; Heterologous expression ; Xenopus laevis oocytes ; Modulation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract In Xenopus laevis oocytes injected with rat brain poly(A)+ RNA, perfusion with a high-K+ solution (96 mM KCl) generated an inward current (I HK) which was absent in water-injected oocytes. Part of I HK was blocked by low concentrations of Ba2+ (half-maximal inhibitory concentration, IC50: 4.2 ± 0.5 μM). When serotonin (5-HT) was applied to these oocytes a transient inward oscillating Cl− current arising from activation of Ca2+ -dependent Cl− channels, I Cl (Ca), was observed. When this response decayed, a 30% reduction of I HK could be detected. Electrophysiological characterization of the K+ channel down-modulated by 5-HT revealed that it is an inward rectifier. Anti-sense suppression experiments revealed that the 5-HT2C receptor mediates the down-modulatory effect of 5-HT. The nature of the modulatory pathway was investigated by application of phorbol esters and intracellular injection of protein kinase C (PKC) inhibitors, ethylenebis (oxonitrilo)tetraacetate (EGTA) and inositol 1, 4, 5-trisphosphate. The results demonstrate that PKC is responsible for the down-modulatory effect.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02207270
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  • 3
    Digitale Medien
    Digitale Medien
    Excited state properties utilizing effective core potentials (1987)
    New York, NY : Wiley-Blackwell
    International Journal of Quantum Chemistry 32 (1987), S. 539-545 
    Details
    ISSN: 0020-7608
    Schlagwort(e): Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical Physics
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: Effective core potentials are utilized in conjunction with polarization propagator calculations of excited state properties. The propagator method employed is based on an antisymmetrized geminal power wave function as the reference state. Calculations are presented on the low-lying excited states of HF and NaH. All-electron and valence-electron results are compared for HF. The choice of basis set is found to be very important for obtaining good results.
    Zusätzliches Material: 6 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/qua.560320753
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  • 4
    Digitale Medien
    Digitale Medien
    The antisymmetrized geminal power approximation to the excitation propagator (1985)
    New York, NY : Wiley-Blackwell
    International Journal of Quantum Chemistry 27 (1985), S. 769-780 
    Details
    ISSN: 0020-7608
    Schlagwort(e): Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical Physics
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: A consistent propagator approximation, denoted as the excitation propagator, is introduced. This propagator describes excitations between N-particle states and its approximation has properties required of consistent random phase approximation schemes. Several properties of this propagator are explored when based on a generalized antisymmetrized geminal power wavefunction. How singularities in the metric occur and how to remove them is discussed in detail. The excitation propagator is also contrasted with the principal (polarization) propagator.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/qua.560270611
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  • 5
    Digitale Medien
    Digitale Medien
    Semiempirical calculation of the hyperpolarizabilities of polyenes (1990)
    New York, NY : Wiley-Blackwell
    International Journal of Quantum Chemistry 38 (1990), S. 791-798 
    Details
    ISSN: 0020-7608
    Schlagwort(e): Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical Physics
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: Semiempirical finite-field methods based on the MNDO, AM1, and PM3 Hamiltonians are employed to study the hyperpolarizability of polyenes {H(C2H2)nH, n = 2, 20}. These results are compared with ab initio results. Also of interest is the large n behavior and methods to extract a value per subunit are explored.
    Zusätzliches Material: 5 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/qua.560382477
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  • 6
    Digitale Medien
    Digitale Medien
    Calculation of the nonlinear optical properties of molecules (1990)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Computational Chemistry 11 (1990), S. 82-87 
    Details
    ISSN: 0192-8651
    Schlagwort(e): Computational Chemistry and Molecular Modeling ; Biochemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Informatik
    Notizen: A finite-field method for the calculation of polarizabilities and hyperpolarizabilities is developed based on both an energy expansion and a dipole moment expansion. This procedure is implemented in the MOPAC semiempirical program. Values and components of the dipole moment (μ), polarizability (α), first hyperpolarizability (β), and second hyperpolarizability (γ) are calculated as an extension of the usual MOPAC run. Applications to benzene and substituted benzenes are shown as test cases utilizing both MNDO and AM1 Hamiltonians.
    Zusätzliches Material: 2 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jcc.540110110
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