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  • 1
    Digitale Medien
    Digitale Medien
    Iotrolan in pediatric examinations (1995)
    Springer
    European radiology 5 (1995), S. S69 
    Details
    ISSN: 1432-1084
    Schlagwort(e): Iotrolan ; Contrast agents ; Iohexol
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Iotrolan, a new non-ionic, dimeric, iodinated contrast agent, was compared with iohexol, a non-ionic, monomeric contrast agent, for suitability in pediatric patients. Two studies were performed. The gastrointestinal medication was studied in 20 infants using iotrolan 300 versus iohexol 300. Contrast quality with iotrolan 300 appears to be superior to iohexol 300. The renal indication was studied in a large, multicenter, double-blind trial, 167 children received intravenous doses of either iotrolan 280 or iohexol 300 for urography, and contrast quality and safety were assessed. Iotrolan 280 appears to give better contrast quality in all areas of the kidney and the ureters. On the results of our experience, we recommend iotrolan 300 for gastrointestinal imaging in pediatries, where barium sulfate is contraindicated, and iotrolan 280 in pediatric urography. We suggest that iotrolan 280 may also be suitable for all intravascular administrations.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02343265
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  • 2
    Digitale Medien
    Digitale Medien
    Iotrolan in urography: efficacy and tolerance in comparison with iohexol and iopamidol (1995)
    Springer
    European radiology 5 (1995), S. S63 
    Details
    ISSN: 1432-1084
    Schlagwort(e): Iotrolan ; Iohexol ; Iopamidol ; Urography
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Iotrolan was compared with iohexol and iopamidol for efficacy and general tolerance in excretory urography in three controlled, randomized, inte-individual, double-blind studies. Two hundred and eighty-four patients received fixed doses of 100 ml, 120 ml or 150 ml iotrolan 280 or iohexol 300/iopamidol 300 by rapid or bolus injection. Contrast quality in films taken 3–40 min after injection was rated by experienced radiologists both on an overall basis and with regard to distinct anatomical regions (parenchyma, pelvicalyceal system, ureter, bladder). In all studies, contrast quality was assessed as better in the iotrolan group. In two studies (dosages 100 and 120 ml), significant differences in contrast quality were found in lavour of iotrolan (P 〈 0.05), and in the third study (dosage 150 ml) there was a trend towards better contrast quality in the iotrolan group (P = 0.06). General tolerance of iotrolan was good with only minor side effects (iotrolan 6.3%, iohexol/iopamidol 9.9%), but the difference was not significant. No severe adverse reactions were observed with iotrolan. In comparison with non-ionic monomers, iotrolan shows very good efficacy and general tolerance for excretory urography.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02343264
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Clinical safety assessment of iotrolan 280 in European clinical studies (1995)
    Springer
    European radiology 5 (1995), S. S85 
    Details
    ISSN: 1432-1084
    Schlagwort(e): Iotrolan ; Iohexol ; Iopamidol ; Iopromide ; Contrast agents ; Safety assessment
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Iotrolan (280 mg iodine/ml) a new non ionic, isotonic dimeric, contrast agent, was evaluated in multicenter clinical stidues conducted in Europe between March 1987 and September 1992. The studies compared the efficacy and safety of the agent with the non-ionic monomeric contrast agents available at the time. Iotrolan was given intravenously to patients undergoing urography, head and body computed tomography phlebography and digital subtraction angiography. The agent was also studied after intra-arterial injections in cerebral, visceral and peripheral angiographic procedures as well as digital subtraction angiography. Data from 32 prospective double blind, randomized, controlled clinical studies, were evaluated. A total of 1203 patients received either iopromide, iohexol or iopamidol (all in concentration of 300 mg iodine/ml), and a further 1207 patients received iortrolan. As there were no sognificant differences (P = 0.0853) in adverse events between the comparative agents, their adverse event data were pooled for evaluation with data from patients receiving iotrolan. Adverse experiences were recorded in two categories — local tolerance (heat and pain) and general tolerance (generalized heat and adverse clinical events). After intra-arterial injection iotrolan had a significantly lower incidence of local heat sensation (P = 0.0001) and a significantly lower incidence of local pain (P = 0.0001) compared with comparator agents. Also, after intravenous injection iotrolan had a significantly lower incidence of local heat (P = 0.0038). In the overall evaluation of general tolerance for all indications, iotrolan was shown to produce significantly less generalized heat (P = 0.0012) and a lower incidence of adverse events (P = 0.061) compared with the reference agents.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02343268
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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