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  • 1
    Digitale Medien
    Digitale Medien
    Springer
    European journal of clinical pharmacology 25 (1983), S. 369-373 
    ISSN: 1432-1041
    Schlagwort(e): pengitoxin ; pharmacokinetics ; 16-acetylgitoxin ; absorption ; urinary excretion ; healthy subjects ; cardiac glycoside
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The pharmacokinetics of pengitoxin has been studied in 28 healthy subjects after intravenous and oral administration. The mean plasma concentration 24 h after 0.5 mg i.v. was 5.2 ng · ml−1. Following an open two-compartment model a mean elimination half-life of 60.5 h (24.9 to 103.5 h) and a mean volume of distribution (Vdarea) of 66.91 (31.8 to 109.61) were calculated. Absorption calculated by comparison of the AUC0-∞-values amounted to 99%. Within 4 days, 16.7% (11.7 to 21.1%) or 27.8% (18.4 to 33.7%) (0.5 mg i.v. or 1.2 mg p.o.) was excreted in urine. After pengitoxin 0.5 mg i.v. total body clearance and renal clearance were 13.3 ml · min−1 (7.0 to 18.6 ml · min−1) and 3.0 ml · min−1 (1.9 to 3.9 ml · min−1) respectively. The elimination half-life of pengitoxin is longer than that of digoxin and distinctly shorter than that of digitoxin, whilst its distribution volume and clearance are closer to those of digitoxin than of digoxin.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Applied physics 45 (1988), S. 113-120 
    ISSN: 1432-0649
    Schlagwort(e): 78.65 ; 72.20 ; 72.40
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract There are a great variety of optical nonlinearities that can lead to the phenomenon of laser-induced gratings (LIG) in semiconductors. In the present contribution the dynamic behaviour of an induced absorber with intrinsic bistability is investigated under excitation in a LIG self-diffraction arrangement. Using CdS as a model substance, the comparison of our theoretical model with our experimental findings gives an insight into the nonlinear dynamics of the degenerate carrier system and also an estimation of the transport properties of the electron-hole plasma.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    ISSN: 1433-044X
    Schlagwort(e): Schlüsselwörter Arthroskopische Kapsel-Labrum-Refixation ; Akute und chronische Schulterluxationen ; Isokinetik ; Key words Acute and chronic shoulder instability ; Arthrosopic suture repair ; Isokinetic
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: We examined 30 patients with an arthroscopic suture repair for anterior shoulder instability in a retrospective evaluation. The follow-up period ranged from 12 to 58 months with an average of 22 months. Arthroscopic suture repairs were done on 14 patients (acute group, average age 26.1 years) with acute detached glenoid labrum, confirmed on arthro-CT, within 10 days after the injury and on 16 patients (secondary group, average age 25 years) with chronic should dislocation. The evaluation according to the Rowe scale resulted in a mean score of 97.1 for the acute group, compared with 92.7 for the secondary group. In each group we found one recurrent dislocation, which in the acute group was due to an adequate trauma. Two of the 14 acute group patients showed a reduction in external rotation of up to 20°, compared with 6 patients in the secondary group. The external rotation of one patient in the secondary group was reduced to 40°. The isokinetic muscle strength was decreased in both groups, both for 60°/s and for 120°/s, to 85% compared with the healthy side. The primary surgical therapy of young patients (below 25 years) with an acute shoulder dislocation and a detached glenoid labrum is recommended owing to the lower redislocation rate, an overall shortened course of treatment and a trend to better postsurgical range of motion.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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