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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nutrition 30 (1991), S. 131-137 
    ISSN: 1436-6215
    Keywords: D-Laktat ; Joghurt ; Mahlzeiteneinfluß ; D-lactate ; yogurt ; ingestion effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Description / Table of Contents: Summary The risk of D-lactic acidosis after consumption of yogurt was investigated in seven healthy volunteers. After ingestion of yogurt containing 1.06 mmol/kg body weight, D-lactic acid postprandial plasma D-lactate concentrations increased from 0.070±0.020 to a maximum of 0.200±0.010 mmol/l within 60 min. That was half the maximum concentration after the equivalent amount of D-lactate in the form of an aqueous solution of DL-lactate. The shape of the postprandial plasma D-lactate peak was flatter, but much broader after yogurt than after the aqueous solution, the peak areas being equal. When 0.64 mmol/kg body weight D-lactate were consumed as yogurt, plasma concentrations amounted to 0.086±0.030 mmol/l. Signs of a mild, transient, compensated metabolic acidosis, which was apparent in case of the aqueous lactic acid solution did not occur in case of yogurt. It is concluded that the consumption of foods containing D-lactic acid gives no reason for concern in healthy adults.
    Notes: Zusammenfassung Das Risiko einer D-Laktat-Azidose durch Joghurtverzehr wurde bei 7 gesunden Probanden untersucht. Nach dem Verzehr von Joghurt, der eine Aufnahme von 1,06 mmol/kg Körpergewicht D-Milchsäure bewirkte, stiegen die postprandialen Plasma-D-Laktat-Spiegel innerhalb von 60 min von 0,070±0,020 auf einen Höchstwert von 0,200±0,010 mmol/l an. Ein doppelt so hoher Anstieg der postprandialen Plasma-D-Laktat-Konzentrationen wurde nach Verabreichung der äquivalenten Menge D-Milchsäure in Form einer wäßrigen Lösung von DL-Laktat beobachtet. Die postprandialen Plasma-D-Laktat-Maxima fielen nach Joghurt flacher und breiter aus, während die Kurvenflächen unabhängig von der Zufuhrform waren. Nach dem Verzehr von 0,64 mmol/kg Körpergewicht D-Milchsäure in Joghurt stiegen die D-Laktat-Konzentrationen im Plasma bis auf 0,086±0,030 mmol/l an. Anzeichen einer geringfügigen, vorübergehenden, kompensierten metabolischen Azidose nach Zufuhr der wäßrigen D-Milchsäure-Lösung wurden nach Verzehr von Joghurt nicht beobachtet. Aus diesen Ergebnissen wird der Schluß gezogen, daß der Verzehr D-Milchsäure-haltiger Lebensmittel für gesunde Erwachsene unbedenklich ist.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 66 (1988), S. 135-143 
    ISSN: 1432-1440
    Keywords: Serum cholesterol ; Nutrition ; Dietary protein ; Thyroxine ; Mechanism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Different dietary proteins determine different serum cholesterol levels if fed in a semisynthetic diet to some, but not all, animal species. In one species, the rabbit, this metabolic response is elicited without adding high sucrose or cholesterol supplements that have to be added to rat or pig diets in order to cause a similar response. Eleven out of 13 studies show that casein and soy protein do not induce different serum cholesterol levels in normal man. More important, protein-induced differences of serum cholesterol concentrations have not been reported when appropriate nutritional methodology has been applied. We conclude that no protein-induced hypercholesterolemia is observed in primates, particularly not in the human species. Dietary recommendations urging the general public to reduce consumption of animal protein because of a higher atherogenicity are not supported by the present data. The biochemical basis of the metabolic responses has been studied by many investigators, but no convincing unifying concept has yet been identified. The recent observation of higher serum thyroxine concentrations following soy protein consumption (and vegetable protein in general) when compared to casein shed new light on this problem. This endocrine response explains a wide array of metabolic features of soy-fed rodents: the lower hepatic VLDL secretion, the higher hepatic HMG-CoA reductase activity, the higher hepatic apo B, E receptor activity, the higher fecal bile acid excretion, and finally the lower serum cholesterol concentrations.
    Type of Medium: Electronic Resource
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