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  • Juvenile chronic arthritis  (2)
  • Aortic constriction  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Adenosine induced fall in glomerular capillary pressure (1981)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 317 (1981), S. 86-89 
    Details
    ISSN: 1432-1912
    Keywords: Glomerular capillary pressure ; Munich-Wistar rat ; Adenosine ; Ureteral obstruction ; Aortic constriction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of acute ureteral obstruction (UO) and reduction of renal artery pressure (AC) on the adenosineinduced renal vasoconstriction was studied in the Munich-Wistar rat. Infusion of adenosine, 0.05 μmol/min · kg body weight, into the thoracic aorta, was associated with a fall of directly measured glomerular capillary pressure (P gc) from 45.2+1.8 to 32.5+1.7 mm Hg, P〈0.001. Elevation of ureter pressure to 39+2 mm Hg abolished the fall of P gc following adenosine infusion, 51.3+1.7 vs. 50.0+1.3 mm Hg, NS. Reduction of renal artery pressure to 70 mm Hg by an aortic clamp above the renal arteries also prevented the fall of P gc due to adenosine, 36.8+0.9 vs. 36.4+1.8 mm Hg, NS. Administration of indometacin (10 mg/kg i.v.) restored the ability of adenosine to reduce P gc in UO from 41.5+1.1 to 25.9+2.6 mm Hg (P〈0.001) and in AC from 34.0+3.4 to 28.2+75.7 mm Hg (P〈0.02). Since previous studies have demonstrated that in UO and AC renal prostaglandin synthesis is enhanced the effects of indometacin suggest that prostaglandins could be antagonistic to the action of adenosine on the kidney. The data show that the renal vasculature becomes insensitive to the vasoconstrictive action of adenosine during elevated ureter pressure and reduced renal artery pressure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00506263
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A model for the role of HLA-DQ molecules in the pathogenesis of juvenile chronic arthritis (1991)
    Springer
    Rheumatology international 11 (1991), S. 191-197 
    Details
    ISSN: 1437-160X
    Keywords: Juvenile chronic arthritis ; MHC-class II association ; HLA-DQ molecules ; Restriction fragment length polymorphism ; Arthritogenic peptide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Restriction fragment length polymorphism (RFLP) typing of MHC-class II loci DRB, DQA1, DQB1, DQA2 and DPB1 was performed in 94 patients with seronegative juvenile chronic arthritis (JCA) and 184 random controls. Analysis of allele frequencies and MHC-class II 4-loci haplotypes indicate: (1) Susceptibility to JCA is more strongly associated with the HLA-DQ subregion than with the HLA-DR subregion, especially in early onset pauciarticular JCA (EOPA-JCA). (2) Haplotype and sequence analysis show two independent MHC-class II associations for susceptibility to EOPA-JCA, one located in DQA1, the other in DPB1. (3) Two RFLP defined patterns of the DQA1 locus, DQA1.5 (DQA1*0501) and DQA1.8 (DQA1*0401, *0601) are strongly associated with the disease. (4) Analysis of amino-acid (AA) sequences coded in exon 2 of DQA1 reveals an AA sequence of six AAs common to all three associated DQA1 alleles. This suggests a model that includes a functional role for HLA-DQ molecules in the pathogenesis of JCA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00332561
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Class I associations and frequencies of class II HLA-DRB alleles by RFLP analysis in children with rheumatoid-factor-negative juvenile chronic arthritis (1993)
    Springer
    Rheumatology international 13 (1993), S. 83-88 
    Details
    ISSN: 1437-160X
    Keywords: Juvenile chronic arthritis ; Early onset ; Juvenile rheumatoid arthritis ; HLA-DRB alleles
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A total of 94 patients with juvenile chronic arthritis (JCA) was tested for HLA class I by serology and for class II by RFLP typing. Early onset JCA (EOPA) is associated with HLA-A2, DR5 and DR8 in both males and females. The combination (joint occurrence) of these JCA associated alleles (A2, DR5, DR8) is frequently seen in patients with chronic iridocyclitis. Late onset pauciarticular disease has an increased frequency of HLA-B27, especially in males. Our data confirm that polyarticular JCA with early childhood onset (≤4 years) is associated with DR5 and DR8 and has a different immunogenetic background from polyarticular JCA with later childhood (〉4 years) onset (associated with DR4).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00307739
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    Paper (German National Licenses)
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