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  • Ketoconazole  (2)
  • Organic Chemistry  (2)
  • Seckel syndrome  (2)
  • 1
    Digitale Medien
    Digitale Medien
    Different inhibitory effect of etomidate and ketoconazole on the human adrenal steroid biosynthesis (1993)
    Springer
    Journal of molecular medicine 71 (1993), S. 933-938 
    Details
    ISSN: 1432-1440
    Schlagwort(e): Etomidate ; Ketoconazole ; Steroid biosynthesis ; Adrenal gland ; Human
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The narcotic agent etomidate and the antimycotic drug ketoconazole are known to block steroid biosynthesis in man. To study the different effects of these imidazole derivatives on human adrenal steroid biosynthesis we incubated slices of human adrenal glands with 3H-labeled precursors and increasing concentrations of etomidate or ketoconazole (0-2000 μM). After extraction the labeled metabolites were separated by thin-layer chromatography and quantified by scintillation counting. Etomidate inhibited most potently 11β-hydroxylase activity by suppressing the formation of corticosterone from 11-deoxycorticosterone to 1 % of control [50% inhibitory concentration (IC50) 0.03 μM] while ketoconazole suppressed 11β-hy-droxylase to only 39% of control activity (IC50 15 μM). Ketoconazole however, most potently blocked the conversion of 17α-hydroxy-proges-terone to androstenedione by C17,20-desmolase to about 15% of control activity (IC50 1 μM) while etomidate showed a much weaker effect on this enzyme with a suppression to 50% of C17,20-desmolase control activity at a concentration of 380 μM. Both imidazole drugs showed a similar strong inhibitory effect on the activity of 17α-hy-droxylase (IC50 6-18 μM) and 16α-hydroxylase (IC50 4–8 μM) and did not affect 21-hydroxylase. These in vitro data indicate a predominant inhibitory effect of etomidate on corticosteroid biosynthesis by relative selective inhibition of 11β-hydroxylase and of ketoconazole on the adrenal androgen biosynthesis by a predominant inhibition of C17,20-desmolase. This differential inhibitory effect of etomidate and ketoconazole on human steroid biosynthesis may be of clinical importance for a possible therapeutic use of these imidazole derivatives in endocrine disorders.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00185607
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  • 2
    Digitale Medien
    Digitale Medien
    Case report (1996)
    Springer
    European journal of pediatrics 155 (1996), S. 796-799 
    Details
    ISSN: 1432-1076
    Schlagwort(e): Key words Bird-headed dwarfism ; Craniosynostosis ; Microcephalic ; osteodysplastic primordial dwarfism ; Osteodysplastic primordial ; dwarfism ; Seckel syndrome
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We report on a 13-month old boy with microcephalic osteodysplastic primordial dwarfism (MOPD), whose radiographic signs correspond with type II of this entity. Some of his clinical signs, such as the anomalies of the external genitalia and the urinary tract, are common to this subgroup of MOPD, but he also shows unusual clinical signs including bilateral knee dislocation and hypoplasia of the anterior corpus callosum. His clinical course was unusual with several episodes of breathing difficulties and increased intracranial pressure secondary to craniosynostosis at the age of 16 months. After fronto-orbital advancement for the treatment of brachycephaly, his psychomotor development improved remarkably. Conclusion MOPD type II may have a wider range of expression than previously delineated.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02002910
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  • 3
    Digitale Medien
    Digitale Medien
    Case report (1996)
    Springer
    European journal of pediatrics 155 (1996), S. 796-799 
    Details
    ISSN: 1432-1076
    Schlagwort(e): Bird-headed dwarfism ; Craniosynostosis ; Microcephalic osteodysplastic primordial dwarfism ; Osteodysplastic primordial dwarfism ; Seckel syndrome
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Abstract We report on a 13-month old boy with microcephalic osteodysplastic primordial dwarfism (MOPD), whose radiographic signs correspond with type II of this entity. Some of his clinical signs, such as the anomalies of the external genitalia and the urinary tract, are common to this subgroup of MOPD, but he also shows unusual clinical signs including bilateral knee dislocation and hypoplasia of the anterior corpus callosum. His clinical course was unusual with several episodes of breathing difficulties and increased intracranial pressure secondary to craniosynostosis at the age of 16 months. After fronto-orbital advancement for the treatment of brachycephaly, his psychomotor development improved remarkably. Conclusion MOPD type II may have a wider range of expression than previously delineated.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02002910
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  • 4
    Digitale Medien
    Digitale Medien
    Inhibition of human adrenal androgen secretion by ketoconazole (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 707-712 
    Details
    ISSN: 1432-1440
    Schlagwort(e): Ketoconazole ; Androgens ; Inhibition of adrenal androgen secretion ; Hirsutism ; Hyperandrogenism therapy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The effect of ketoconazole on adrenal androgen secretion was examined in 15 patients with elevated serum androgens. In a dose of 600 mg per day orally ketoconazole inhibited the biosynthesis of all measured androgens. The mean reduction in serum levels of dehydroepiandrosterone sulfate was 32%, of dehydroepiandrosterone 54%, of androstenedione 52%, and of testosterone 43%; mean serum levels of cortisol only fell by 19%. The reduction in serum androgen levels was first significant 24 h after beginning of treatment and persisted as long as the drug was administered. We conclude that ketoconazole inhibits adrenal androgen biosynthesis more pronouncedly than cortisol biosynthesis. This might be of clinical benefit in the treatment of hirsutism and other states of androgen hypersecretion.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01721288
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  • 5
    Digitale Medien
    Digitale Medien
    Flüssigkristalle mit aliphatischen Gruppen zwischen Cyclohexanringen - Synthesen von 1,4-Bis-(4-n-alkylcyclohexyl)butanen und 4-[4-4(4-n-Alkylcyclohexyl)butyl]cyclohexylestern (1992)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 334 (1992), S. 625-629 
    Details
    ISSN: 0941-1216
    Schlagwort(e): Chemistry ; Organic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: Liquid Crystals with Aliphatic Groups between Cyclohexane Rings - Synthesis of 1,4-Bis(4-n-alkylcyclohexyl)butanes and Esters of 4-[4-(4-n-Alkylcyclohexyl)-butyl]cyclohexanolsThe synthesis of 1,4-bis-(4-n-alkylcyclohexyl) butanes (1), esters of 4-[-(4-n-alkylcyclohexyl)butyl]cyclohexanols (2) and some analogous aromatic compounds are described. The thermal stability of mesophases of these compounds are in the order of the analogous ethylene-bridged liquid crystals. The reason for this result seems to be the combination of molecular rigidity and conformational flexibility.
    Zusätzliches Material: 3 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/prac.19923340713
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  • 6
    Digitale Medien
    Digitale Medien
    Flüssig-kristalline Cyclohexan-Derivate mit lateralen Substituenten in der Alkylmittelgruppe (1993)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 335 (1993), S. 205-208 
    Details
    ISSN: 0941-1216
    Schlagwort(e): Chemistry ; Organic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: Liquid Crystalline Derivatives of Cyclohexane with Lateral Substituents in the Middle Group
    Zusätzliches Material: 1 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/prac.19933350217
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