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  • 1995-1999  (2)
  • Key words Lipoprotein lipase  (1)
  • PACS: 36.40.-c Atomic and molecular clusters – 36.40.Mr Spectroscopy and geometrical structure of clusters – 61.46.+w Clusters, nanoparticles, and nanocrystalline materials – 71.24.+q Electronic structure of clusters and nanoparticles  (1)
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Years
  • 1995-1999  (2)
Year
Keywords
  • 1
    ISSN: 1435-1536
    Keywords: Key words Lipoprotein lipase ; inhibition ; phosphatidylcholine ; sphingomyelin ; triglyceride ; monolayer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract  We evaluated the activation and inhibition effects of phosphatidylcholine (PC) and sphingomyelin (SM) on lipoprotein lipase (LPL) for medium or long chain-triglycerides (TG) in monolayers at the air/water interface. Monolayers of medium chain-TG, being in an expanded state at a surface pressure of 15 mN/m, showed low susceptibility to LPL in the subphase. Adding 50 mole% of PC or SM into these monolayers reduced the partial molecular area of the TG and enhanced the LPL activity. Monolayers of long chain-TG, being in a condensed state, showed high susceptibility of LPL either with or without PC. SM added to the long chain-TG monolayers, however, inhibited the LPL action. We investigated the interaction between TG and phospholipid on the basis of the collapse pressure-measurements of mixed monolayers. For medium chain-TG monolayers, PC and SM gave similar collapse pressure-composition profiles. Contrary to this, SM gave a markedly higher collapse pressure of long chain-TG than PC: SM stabilized the monolayer state of long chain-TG. These results suggested that I) orientation of the acyl chains of TG molecule in a monolayer is crucial for the LPL activity, and that II) strong interaction between SM and long chain-TG retards the substrate-transfer from the mixed monolayer to the catalytic pocket of LPL.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1434-6079
    Keywords: PACS: 36.40.-c Atomic and molecular clusters – 36.40.Mr Spectroscopy and geometrical structure of clusters – 61.46.+w Clusters, nanoparticles, and nanocrystalline materials – 71.24.+q Electronic structure of clusters and nanoparticles
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. Organometallic clusters of lanthanide (Ln = Nd, Er, Eu, and Yb) and 1,3,5,7-cyclooctatetraene (C8H8) were produced by a combination of laser vaporization and molecular beam methods. In the mass spectra of [Ln n (C8H8) m ], compositions of m=n+1 were magic numbers. From mass spectrometry, photoionization spectroscopy, and photoelectron spectroscopy, we have concluded that these magic-numbered clusters take multiple-decker sandwich structures in which Ln atoms and C8H8 molecules are alternatedly piled up. These sandwich clusters are formed through ionic bonds composed of multiply charged cations [Ln k+  (k=2 and 3)] and multiply charged anions [C8H8 h-  (h=1, 1.5, and 2)].
    Type of Medium: Electronic Resource
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