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  • 1
    Electronic Resource
    Electronic Resource
    Do tides affect water quality in the upper phreatic zone of a small oceanic island, Sipadan Island, Malaysia? (1997)
    Springer
    Environmental geology 29 (1997), S. 112-117 
    Details
    ISSN: 1432-0495
    Keywords: Key words Water quality ; Tidal change ; Upper phreatic zone ; Oceanic island
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract  Sipadan Island is a small oceanic island with limited storage of fresh groundwater. A study was carried out to determine the effect of tidal change on the groundwater quality of such an island using temperature, dissolved oxygen content, conductivity, salinity, and pH values as indicators. Overall, the results indicated that the groundwater quality changes with tides, but the trends of fluctuation differs between the observed parameters. It was found that the percentages of changes during the period of study were 0.8% (temperature), 53% (dissolved oxygen), 61% (conductivity), 58% (salinity), and 1.7% (pH) at the centre of the island; and 0.9% (temperature), 33% (dissolved oxygen), 40% (conductivity), 42% (salinity), and 9% (pH) at a station 120 m from the coast, based on 2.9-m and 2.8-m tidal ranges at each station.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002540050109
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Comparative pharmacokinetic study of oral and rectal formulations of artesunic acid in healthy volunteers (1998)
    Springer
    European journal of clinical pharmacology 54 (1998), S. 411-414 
    Details
    ISSN: 1432-1041
    Keywords: Key words Artesunic acid ; Pharmacokinetics ; Malaria
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: A single cross-over, comparative pharmacokinetic study of oral and rectal formulations of 200 mg artesunic acid in 12 healthy Malaysian volunteers is reported. Methods: Plasma concentrations of artesunic acid and dihydroartemisinin were determined simultaneously by HPLC with electrochemical detection. The test drug was well tolerated and no undesirable adverse effects were observed. Results: Comparison of pharmacokinetic parameters of artesunic acid after oral and rectal administration showed statistically significant differences in t max and AUC, with no changes for C max and t 1/2. As for dihydroartemisinin, differences were observed for t max and C max but not for AUC. Conclusion: There appear to be pharmacokinetic differences between oral and rectal modes of administration. The significance of these findings should be explored in malaria patients before appropriate therapeutic regimens are devised.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050484
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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