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  • 1
    Electronic Resource
    Electronic Resource
    Analysis of the p53 gene mutations in acute myelogenous leukemia: the p53 gene mutations associated with a deletion of chromosome 17 (1995)
    Springer
    Annals of hematology 71 (1995), S. 83-87 
    Details
    ISSN: 1432-0584
    Keywords: Key words p53 gene ; Acute myelogenous leukemia ; Chromosome 17 ; Polymerase chain reaction ; single-strand conformation polymorphism ; Direct sequencing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  In order to determine the relevance of the p53 tumor suppressor gene mutations in acute myelogenous leukemia (AML), we analyzed the p53 gene in genomic DNA of 18 unselected cases of AML by polymerase chain reaction–single-strand conformation polymorphism (PCR–SSCP) and direct sequencing. We detected three cases (16.7%) with the p53 gene mutations showing only the mutant alleles; the high incidence in cases with loss of a whole chromosome 17 (two of three) contrasted with the low incidence in cases without abnormalities of chromosome 17 (one of 15). These cases containing the mutations of the p53 gene showed a poor prognosis. Although we analyzed a rather small series of patients, these findings suggest that the p53 gene mutations might be involved in the progression and prognosis of at least some cases of AML.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01699251
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Comparative platelet anti-aggregant activity of D-cysteinolic acid analogues (1989)
    Springer
    Cellular and molecular life sciences 45 (1989), S. 1110-1112 
    Details
    ISSN: 1420-9071
    Keywords: D-Cysteinolic acid ; platelet aggregation ; inhibitor ; marine product ; 2-aminoethyl disulfide ; sardine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary D-Cysteinolic acid (1) analogues with an S-C-C-N skeleton showed increased platelet anti-aggregant activity in the following order: 2-aminoethanesulfonic acids, thiazolidines, 2-aminoethanethiols and 2-aminoethyl disulfides. Methyl substitutions at the 2-position potentiated the activity. Of these analogues, bis [(R)-2-aminopropyl] disulfide was the most potent inhibitor of platelet aggregation, with about 600-fold the activity of (1).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01950172
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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