ISSN:
1432-0428
Keywords:
Key words TNFα
;
B7-1
;
transgenic
;
mouse
;
diabetes
;
autoimmunity
;
lymphocytes.
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary While transgenic mice expressing tumour necrosis factor-alpha under the control of the beta-cell-specific insulin promoter display a marked lymphocytic infiltration of the islets, they never develop insulin-dependent diabetes mellitus (IDDM). In striking contrast, “double” transgenic mice whose beta cells express both tumour necrosis factor-alpha as well as the co-stimulatory B7-1 molecule all develop IDDM at an early age. Further, administration of anti-CD8 but not anti-CD4 immunoglobulins prevents diabetes onset. These results indicate that while tumour necrosis factor-alpha induced lymphocytic infiltration is not sufficient to effect beta-cell destruction, locally co-stimulated islet-infiltrating CD8+ T lymphocytes could play a critical role in the development of IDDM. [Diabetologia (1994) 37: 1277–1279]
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00399802
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