ISSN:
1432-0584
Keywords:
Chromosome
;
ANLL
;
Trisomy 4
;
L-CFU
;
CFU mix
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary We report here the development, 8 years after radiation therapy for breast cancer, of acute nonlymphocytic leukemia (ANLL), type M2 of the FAB classification, in which trisomy 4 was detected as the only chromosomal abnormality. Simultaneous observation of cytologic and cytogenetic features of individual colonies derived from leukemic progenitor (L-CFU) and early progenitor (CFU mix) cultures in this patient revealed that all colonies examined had a normal karyotype, although the clone with trisomy 4 was predominant in the direct bone-marrow culture. These findings suggest that progenitor cells with trisomy 4 were less predominant in colony growth when stimulated by colony-stimulating factors (CSFs) than were stem cells with a normal karyotype.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00320232
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