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  • 1
    Electronic Resource
    Electronic Resource
    Full sequence of neurocalcin, a novel calcium-binding protein abundant in central nervous system
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 185 (1992), S. 147-153 
    Details
    ISSN: 0006-291X
    Keywords: [abr] PAGE; polyacrylamide gel electrophoresis ; [abr] PCR; polymerase chain reaction ; [abr] SDS; sodium dodecyl sulfate ; [abr] Tricine; Tris(hydroxymethyl)methylglycine ; [abr] bp; base pairs
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0006-291X(05)80968-4
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Full sequence of neurocalcin, a novel calcium-binding protein abundant in central nervous system
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 185 (1992), S. 147-153 
    Details
    ISSN: 0006-291X
    Keywords: [abr] PAGE; polyacrylamide gel electrophoresis ; [abr] PCR; polymerase chain reaction ; [abr] SDS; sodium dodecyl sulfate ; [abr] Tricine; Tris(hydroxymethyl)methylglycine ; [abr] bp; base pairs
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0006-291X(05)80968-4
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Familial amyloidotic polyneuropathy (ATTR Ser50Ile): the first autopsy case report (2000)
    Springer
    Virchows Archiv 436 (2000), S. 345-350 
    Details
    ISSN: 1432-2307
    Keywords: Key words Amyloidosis ; ATTR Ser50Ile ; Autopsy ; Familial amyloidotic polyneuropathy ; Transthyretin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We report an autopsy case of a pedigree of familial amyloidotic polyneuropathy (FAP) with a mutation of isoleucine-50 transthyretin (ATTR Ser50Ile). A 47-year-old man started developing severe diarrhea and weight loss at age 41 years, followed by urinary incontinence, autonomic-nervous-system abnormalities and serious heart failure; the diagnosis of FAP (ATTR Ser50Ile) was made on the basis of genetic, histochemical and immunohistochemical analysis. Six years after the initial symptoms, he died of septic shock. Autopsy revealed suppurative peritonitis, perforation of the sigmoid colon and marked systemic amyloid deposition. The total amount of amyloid deposited in the heart was greatly increased and was much lower in the thyroid gland and kidneys compared with amyloid deposits in ordinary FAP (ATTR Val30Met). Amyloid deposition in peripheral vessel walls was prominent, particularly in lymphatics and veins. His elder sister, 54 years old, started to develop orthostatic hypotension at age 49 years, followed by dysesthesia, diarrhea and severe congestive heart failure. Endomyocardial biopsy revealed severe TTR–amyloid deposition; ultrastructural examination demonstrated that amyloid fibrils were deposited disproportionately and extended radially around microvessels. These characteristic patterns of systemic amyloid deposition and distinct clinical manifestations, especially in the cardiovascular system, are considered to be a characteristic feature of ATTR Ser50Ile amyloidosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280050457
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  • 4
    Electronic Resource
    Electronic Resource
    Changed affinity of apolipoprotein AII to high density lipoprotein (HDL) in patients with familial amyloidotic polyneuropathy (FAP) type I
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Molecular Basis of Disease 1225 (1994), S. 311-316 
    Details
    ISSN: 0925-4439
    Keywords: Apolipoprotein AI ; Apolipoprotein AII ; Familial amyloidotic polyneuropathy ; High density lipoprotein ; Transthyretin
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0925-4439(94)90012-4
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  • 5
    Electronic Resource
    Electronic Resource
    Interaction of 5-fluorouracil with sodium poly-α,L-glutamate (1985)
    Springer
    Colloid & polymer science 263 (1985), S. 682-685 
    Details
    ISSN: 1435-1536
    Keywords: 5-trifluorouracial ; sodium poly-α ; L-glutamate ; interaction ; viscosity ; 5-trifluoromethyluracil
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The purpose of our research is to obtain an understanding of the binding mechanism and its correlations in terms of chemical structure and the potentiactive drug activity. The interaction of 5-fluorouracil (5-fluorouracil is used as an anticancer drug) with sodium poly-α,L-glutamate in aqueous solution was studied with a spectral method and viscosity measurement. From the binding data, the molar change in enthalpy, entropy and the number of binding sites on the polymer were calculated. It is very interesting that the value ofΔH0 of the binding of 5-fluorouracil with sodium poly-α,L-glutamate is smaller than that of 5-trifluoromethyluracil (although 5-trifluoromethyluracil is not used as an anticancer drug, the compound has a similar structure to 5-fluorouracil).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01419893
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  • 6
    Electronic Resource
    Electronic Resource
    Interaction of malachite green or acridine orange and sodium poly-a,L-glutamate (1981)
    Springer
    Colloid & polymer science 259 (1981), S. 774-774 
    Details
    ISSN: 1435-1536
    Keywords: Malachite green ; acridine orange ; Na-poly-a ; L-glutamate ; Interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01419326
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  • 7
    Electronic Resource
    Electronic Resource
    Interaction of 1-(2-tetrahydrofuryl)-5-fluorouracil with sodium poly-α,L-glutamate (1981)
    Springer
    Colloid & polymer science 259 (1981), S. 350-353 
    Details
    ISSN: 1435-1536
    Keywords: Anticancer drug ; 1-(2-tetrahydrofuryl)-5-fluorouracil ; Sodium poly-α ; L-glutamate ; Interaction ; Viscosity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Zusammenfassung Die Wechselwirkung zwischen 1-(2-Tetrahydrofuryl)-5-fluorouracil und Na-Poly-α,L-glutamat wurde mit den Methoden der Spektroskopie und der Viskositätsmessung untersucht. Aus den Bindungsdaten wurden die molare Änderung von Entropie und Enthalpie und die Zahl der Brückenstellen des Polymeren berechnet. Der Wert von ΔG° beträgt ca. −10 Kcal/mol. Die Affinität ist also sehr groß.
    Notes: Summary The interaction of an anticancer drug, 1-(2-tetrahydrofuryl)-5-fluorouracil with sodium poly-α,L-glutamate in aqueous solution was studied with a spectral method and viscosity measurement. From the binding data, the molar change in enthalpy, entropy and the number of binding sites on polymer were calculated. The standard affinity of 1-(2-tetrahydrofuryl)-5-fluorouracil is about −10 kcal/ol with sodium poly-α,L-glutamate. The affinity is also very high.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01524715
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