ISSN:
1432-0584
Keywords:
Platelet
;
Lactic dehydrogenase
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Mean lactic dehydrogenase (LDH) activity of human platelets is about 5 nU/platelet; expressed on a cell volume basis, it is 0.5 nU/fl. Platelet separation by means of centrifugation on a Percoll discontinuous gradient gives different subpopulations with a clear-cut change of LDH at a mean platelet volume (MPV) of about 6 fl. The LDH content of platelets with a MPV 〉6 fl is constant (about 0.5 nU/fl), while that of small platelets (3〈MPV〈6 fl) is inversely correlated with the MPV and reaches a value of 1.5–2.0 nU/fl. Because small platelets are granule-depleted, we suggest that platelet LDH activity be considered as an in vivo activation index.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01695813
Permalink
