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  • 1
    Electronic Resource
    Electronic Resource
    Lacticacidosis, neurological deterioration and compromised cellular pyruvate oxidation due to a defect in the reoxidation of cytoplasmically generated NADH (1983)
    Springer
    European journal of pediatrics 140 (1983), S. 98-101 
    Details
    ISSN: 1432-1076
    Keywords: Lacticacidosis ; Neurological deterioration ; Redox disequilibrium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two patients, one dying at 25 days and one at 20 months had ‘chronic’ lactic acidaemia with a high lactate to pyruvate ratio. Both showed EEG abnormalities and seizure activity and both died of respiratory failure. Investigation of cultured skin fibroblasts from these patients revealed normal pyruyate dehydrogenase and pyruvate carboxylase activities but the cells showed a decreased ability to oxidise pyruvate which was returned to normal on the addition of methylene blue. Subsequent investigations revealed that the mitochondria from the patients' cells could oxidise pyruvate normally but that the cells had an abnormal NAD to NADH ratio under standard conditions of incubation. It was concluded that both children had a redox disequilibrium in the cytoplasmic compartment due to a problem in transporting reducing equivalents from the cytoplasmic to the mitochondrial compartments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441651
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    On sensitivity in optimal control problems (1974)
    Springer
    Journal of optimization theory and applications 13 (1974), S. 56-73 
    Details
    ISSN: 1573-2878
    Keywords: Sensitivity analysis ; control theory ; mathematical programming ; method of multipliers ; Banach spaces
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract Two types of interpretations of multipliers in both static and dynamic optimization problems are described. It is snown that the Lagrange multipliers encountered in mathematical programming problems and the auxiliary functions arising in Pontryagintype optimal control problems sometimes have highly analogous interpretations as rates of change of the optimal attainable value of an objective function, or in some cases as bounds on average rates of change.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00935609
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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