ISSN:
1432-0533
Schlagwort(e):
Leucodystrophy
;
Myelin
;
Cattle
;
Oligodendrocyte
;
Node of Ranvier
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Summary The pathology of a recently recognised progressive disorder of myelin in mature Charolais cattle is described. Clinical signs are first noticed at 8–24 months of age and progress from slight ataxia to recumbency over a period of 1–2 years. Lesions are microscopic and restricted to the white matter of the central nervous system. They are most marked in the internal capsule, cerebellar white matter and spinal cord and consist of multiple eosinophilic plaques. Ultrastructurally the lesions are associated with the nodal region of the myelin sheath. They are composed of disordered myelin, hypertrophied and hyperplastic oligodendrocytic tongues and many small processes which originate from these. There is evidence of myelin breakdown, but this does not elicit a phagocytic response. The aetiology of this condition is not known but the nature of the pathological process suggests a basic derangement of the myelin bearing cell.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00684771
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