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Digitale Medien

Dynamic aspects of affinity labelling as revealed by alkylation and phosphorylation of pancreatic ribonuclease with reactive deoxyribodinucleotide derivatives

Knorre, D.G. ; Buneva, V.N. ; Baram, G.I. ; [weitere]

Amsterdam : Elsevier

FEBS Letters 194 (1986), S. 64-68

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ISSN: 0014-5793

Schlagwort(e): Affinity labeling Biopolymer dynamics Reactive dinucleotide derivative

Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Thema: Biologie , Chemie und Pharmazie , Physik

Materialart: Digitale Medien

URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(86)80052-7

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Digitale Medien

Growth inhibition of pancreatic tumor cells by modified antisense oligodeoxynucleotides (1998)

Fiedler, Alexander ; Knorre, Christoph ; Franke, Yvonne ; [weitere]

Springer

Langenbeck's archives of surgery 383 (1998), S. 269-275

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ISSN: 1435-2451

Schlagwort(e): Key words Pancreatic cancer ; p53 ; Antisense oligodeoxynucleotides ; Cell culture

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Introduction: Pancreatic adenocarcinomas are largely resistant to apoptosis. More than 50% of pancreatic tumors reveal mutations in the p53 tumor suppressor gene. Methods: We investigated the growth of pancreatic tumor cells after downregulation of p53 protein expression by antisense oligodeoxynucleotides. Results: Proliferation and p53 expression of PancTu-I cells overexpressing mutant p53 protein were inhibited by antisense oligodeoxynucleotide treatment. When analyzed, two of three other pancreatic tumor cell lines with mutated p53 were also inhibited in their growth. Two of two wild-type (wt) p53 pancreatic tumor cells were not significantly influenced by p53 expression and were, only to a lesser extent, affected in their proliferation. K562 cells (lacking p53 mRNA) and normal human skin fibroblasts used as a target mismatch control showed no changes in proliferation rates with treatment. The different biological effects in the various cells were not caused by differences in the uptake of the oligodeoxynucleotides as monitored by confocal laser-scanning microscopy. Conclusions: Truncation and 5′- and 3′-lipophilic modifications of the oligodeoxynucleotides drastically enhanced the growth inhibition of PancTu-I cells, which were resistant to apoptosis-inducing agents. Furthermore, a higher sequence-specificity of the observed effects was achieved with these compounds.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/s004230050131

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Digitale Medien

Aspekte der Situationserkennung an Fermentationsprozessen (1987)

Pohl, H.-D. ; Knorre, W. A.

Berlin : Wiley-Blackwell

Acta Biotechnologica 7 (1987), S. 507-513

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ISSN: 0138-4988

Schlagwort(e): Life Sciences ; Life Sciences (general)

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: The establishment of an on- or off-line-optimal-controlled fermentation process requires a system of situation identification - process rearrangement. The choice of the structure and the mathematical model of the situation is difficult. To characterize the situation it is necessary to determine the process-specific vector which regards the major features of the processes. The determination of the structur and the vector which regards the major features of the fermentation process has been demonstrated by several examples.

Zusätzliches Material: 3 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/abio.370070606

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Digitale Medien

FERM - a decision support system for fermentation processes (1990)

Guthke, R. ; Schulz, V. ; Knorre, W. A. ; [weitere]

Berlin : Wiley-Blackwell

Acta Biotechnologica 10 (1990), S. 63-71

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ISSN: 0138-4988

Schlagwort(e): Life Sciences ; Life Sciences (general)

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: For recombinant DNA product fermentations in the laboratory and pilot scale as well as for antibiotic fermentations at the industrial scale decision support program systems for personal computers were developed. It assists the operator to solve control and decision tasks. Applying this program the data and knowledge bases increase, which include measured and derived process data, parameters and comments of previous fermentation runs as well as algorithmic and declarative rules.

Zusätzliches Material: 3 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/abio.370100118

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