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  • 6-Hydroxydopamine  (1)
  • Life and Medical Sciences  (1)
  • Sensitivity analysis  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Operant behavioural and neurochemical effects after neonatal 6-hydroxydopamine treatment (1976)
    Springer
    Psychopharmacology 50 (1976), S. 55-60 
    Details
    ISSN: 1432-2072
    Keywords: 6-Hydroxydopamine ; Operant behaviour ; Noradrenaline ; Tyrosine hydroxylase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Newborn rats were treated at 1 and 2 days after birth with 100 mg/kg 6-hydroxydopamine (6OHDA), s.c. Testing on several operant behavioural tasks was begun at 6 months of age. On a fixed ratio 30 (FR 30) schedule of food reinforcement, the neonatal 6OHDA treated rats responded at a significantly higher rate. Further analysis of the FR 30 response pattern indicated that the higher rate was due to a decrease in the amount of time spent pausing after the receipt of each reinforcer. The 6OHDA treatment failed to alter the rat's behaviour during the extinction of the FR 30 response and on the progressive ratio or variable interval schedules of food reinforcement. Biochemical analysis of several brain areas at 9 months of age showed a decrease in noradrenaline (NA) levels in the cerebral cortex and hippocampus, while in the pons-medulla NA, content was doubled. The tyrosine hydroxylase activity in these same brain areas was not significantly altered, but there appeared to be some decrease in the activity of this enzyme in the hippocampus. Comparison of the operant behavioural effects seen after various lesioning procedures in this and other studies, suggest the effects on FR performance are a result of destruction of NA neurons in the hippocampus and/or the apparent regeneration of neurons in the pons-medulla.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00634155
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    On sensitivity in optimal control problems (1974)
    Springer
    Journal of optimization theory and applications 13 (1974), S. 56-73 
    Details
    ISSN: 1573-2878
    Keywords: Sensitivity analysis ; control theory ; mathematical programming ; method of multipliers ; Banach spaces
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract Two types of interpretations of multipliers in both static and dynamic optimization problems are described. It is snown that the Lagrange multipliers encountered in mathematical programming problems and the auxiliary functions arising in Pontryagintype optimal control problems sometimes have highly analogous interpretations as rates of change of the optimal attainable value of an objective function, or in some cases as bounds on average rates of change.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00935609
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Fracture of long bones: Rate effects under singular and combined loading states (1983)
    Hoboken, NJ [u.a.] : Wiley-Blackwell
    Journal of Orthopaedic Research 1 (1983), S. 244-250 
    Details
    ISSN: 0736-0266
    Keywords: Fracture behavior ; Axial-torsional loading ; Life and Medical Sciences
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: This study was undertaken to determine the effect of loading rate on bone failure under singular and combined loading states. Using the entire loading range of an Instron Materials Testing Machine, 190 pairs of canine radii were tested. One bone of each pair was subjected to either torsional or a combination of axial and torsional loads, and compared with a control specimen. Compressive loads of 4.6 and 11.5 N were utilized. Torque to failure and energy data versus loading rate were plotted. As loading rate increased, the torque and energy values were found to increase, reach a peak, and then decline at higher rates. Fractures produced under the combined state of loading are representative of those clinically found in human trauma situations.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jor.1100010303
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    Paper (German National Licenses)
    Fulltext
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