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  • Life and Medical Sciences  (2)
  • corn  (2)
  • non-Hodgkin's lymphoma  (2)
  • 1
    ISSN: 1569-8041
    Keywords: chemotherapy ; dose intensification ; long-term survival ; MACOP-B ; non-Hodgkin's lymphoma ; randomized trial
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: The initial publication of the results of the Australianand New Zealand Lymphoma Group (ANZLG) randomized controlled trial comparingMACOP-B and CHOP in patients with intermediate-grade non-Hodgkin's lymphoma(NHL) showed equivalent complete response rates, time to treatment failure,and survival. Here we report the long-term follow-up of the 236 patientsentered on that study to determine if there were any long-term advantages ordisadvantages associated with MACOP-B. Patients and methods: Two hundred thirty-six eligible patients wererandomized between October 1986 and June 1991. The median duration offollow-up has been extended from 3.2 years in our previous publication to 6.5years. Results: As previously reported, the complete response (CR) rate forMACOP-B and CHOP chemotherapy was 51% and 59%, respectively. Theestimated failure-free survival rate for MACOP-B and CHOP patients was42% and 30%, respectively, at 5 years (P = 0.045) and37% and 25%, respectively, at 8 years (P = 0.057). Theestimated overall survival rate at 5 years was 54% for MACOP-B and41% for CHOP patients (P = 0.035) and at 8 years was 45%and 36%, respectively (P = 0.16). Conclusion: With this extended follow-up, we have shown a long-termsurvival advantage for MACOP-B chemotherapy over standard CHOP inpatients with intermediate-grade non-Hodgkin's lymphoma.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1569-8041
    Keywords: cyclophosphamide ; dose-escalation ; epirubicin ; filgrastim ; G-CSF ; non-Hodgkin's lymphoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: To define a maximum tolerated dose (MTD) for the combination of epirubicin and cyclophosphamide with filgrastim (r-met-HuG-CSF) in patients with advanced solid tumors and non-Hodgkin's lymphoma (NHL). Patients and methods: Thirty-five patients with advanced solid tumors were enrolled in stages I and II. Twenty-one patients were treated in stage I in sequential cohorts of at least three patients at increasing dosage levels of cyclophosphamide and epirubicin, for up to six cycles every 21 days. At the completion of stage I, a MTD for epirubicin was established. Fourteen patients were treated in stage II, in cohorts of three or more. The epirubicin dose remained constant at the MTD dosage from stage I. Cyclophosphamide was further dose-escalated to establish its MTD. Twenty-one patients with previously untreated non-Hodgkin's lymphoma were treated in stage III with the MTD established in the prior stages. Results: The MTD in stage I was epirubicin 150 mg/m2 and cyclophosphamide 1500 mg/m2 with cumulative neutropenia as the dose-limiting toxicity (DLT). Cumulative thrombocytopenia prevented further dose-escalation of cyclophosphamide in stage II. The stage III regimen consisted of six, 21-day cycles of epirubicin 150 mg/m2, cyclophosphamide 1500 mg/m2, vincristine 2 mg, and prednisolone 100 mg for five days with filgrastim support. Nineteen of twenty-one patients (90%) completed six cycles of treatment, eight (38%) without dose reduction. Common toxicity criteria (CTC) grade 4 neutropenia (neutrophil nadir 〈0.5 × 109/l) was documented in 85 of 118 cycles (72%). Neutropenic fever was documented in 17 of 21 patients (81%) on at least one occasion. Severe thrombocytopenia (〈25 × 109/l) was seen in fourteen of 118 cycles (12%) and increased with cycle number. There was no significant non-hematological toxicity. Conclusion: Significant dose-escalation of epirubicin and cyclophosphamide was possible with filgrastim support. The MTD achieved was approximately double that of standard-dose therapy. This study forms the basis of an ongoing randomized study evaluating dose-intensification in intermediate grade NHL.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Plant and soil 177 (1995), S. 235-247 
    ISSN: 1573-5036
    Keywords: corn ; nitrogen availability ; N simulation ; soil ; tillage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract The objective of this study was to determine if a re-calibrated version of the computer model NCSWAP (version 36) could accurately predict corn growth and soil N dynamics in conventionally tilled (CT) and no-till (NT) corn supplied with legume green manure or ammonium nitrate as N sources. We also attempted to ascertain the reasons for limitations in the model's ability to simulate corn growth and soil N dynamics found by our colleagues in a previous study and to propose potential improvements. The model was calibrated to accurately simulate total available N (N in plant above-ground biomass plus soil nitrate in the 0 to 45 cm profile) for a control and a fertilizer CT treatment in the 1992 growing season. To do so, input values defining the quantities of active soil organic N had to be reduced to 19% of the values proposed by the model developers and a solute transport factor defining the mobile vs. immobile fractions of soil nitrate adjusted from 0.8 to 0.2. The discrepancies between the proposed values and the lower values employed in this study might be due to the uncertainties in quantitatively describing soil N mineralization processes and the way they are handled in the model, as well as the lack of a component simulating macroporous-influenced water flow and solute transport in the model. With the current version, until one knows how to predict what these values are, the model needs to be re-calibrated for each experimental site and condition and thus is of limited value as a general model. With no further adjustment of input values, model validation success was mixed. The model accurately predicted total available N for treatments in the second year of the experiment that had the same N source and tillage as the treatments used for the calibration year but with the different weather and growing conditions. However, total available N was underpredicted where legume green manure was the N source and overpredicted with no-till cultivation. The model was accurate in simulating seasonal corn growth for nearly all the treatments, judged by nonsignificant mean difference (MD) values and highly significant correlation coefficients (r). Prediction of seasonal soil nitrate concentration was less accurate compared to total available N and corn growth variables. Potential improvements in the model's simulation of a no-till system as well as for predicting corn harvest yield and seasonal soil nitrate concentration where N deficiency occurs were discussed.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Plant and soil 162 (1994), S. 203-210 
    ISSN: 1573-5036
    Keywords: corn ; hairy vetch ; red clover ; nitrogen availability ; tillage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract It has been shown that legume green manures have great potential for replacing a substantial amount of the N fertilizer required for corn (Zea mays L.) production. An experiment was conducted in central Pennsylvania (USA) to study seasonal fluctuation of nitrogen (N) availability in corn with conventional tillage (CT) and no-till (NT) following red clover (Trifolium pratense L.) and hairy vetch (Vicia villosa Roth) green manures double-cropped with winter wheat (Triticum aestivum L.). Samples of corn, weeds, and soil were taken periodically and analyzed for total N content in plant tissue and soil nitrate-N content. The sum of plant N (corn plus weed) and soil nitrate-N in the upper 45 cm profile was used as an indicator of total available N. Under CT, total available N increased rapidly upon legume incorporation and reached 80% of the maximum within 4 weeks. Under NT, total available N increased steadily after the legumes were killed with herbicides and reached a maximum within 7 to 8 weeks. Seasonal corn N accumulations with the legume N source were similar to those where corn followed fallow with 200 kg N ha−1 fertilizer with CT, but were less than those in the same fallow 200 kg N ha−1 treatment with no-till. Dry weather conditions together with weed competition reduced N availability to the no-till corn compared to the CT treatments. The seasonal fluctuations of total available N and corn N uptake suggest good synchronization between N availability from the legume green manures and N accumulation by corn plants in both tillage systems under the conditions of this study.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 128 (1970), S. 137-145 
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Significant sex and strain differences in correlation of bone, body and skeletal weights show significant localized effects of sex and strain and a combination of both. Individually they seem to lack biological meaning. However, when considered in relation to the ponderal correlations, of which they are a part, they fall into place at the distal ends of a graded linear correlation series, both within and between limbs; and similarly between mandible and sacrum, respectively, with each bone of both limbs. The pattern of these gradients reveals a linear decline in correlation of bones with distance (rule of neighborhood, Karl Pearson) in most cases, but the exceptions are such as can be related to the functions in which they cooperate. In this way they demonstrate at least two major unifying genetic influences. One associates sex and strain with locomotion and the other with the incipient upright investigative posture of the Lagomorphs (including the rabbit). The expected effect of sex on the pelvis is apparently not expressed by these ponderal measurements. The manner in which this correlation approach, based on well established genetic growth differences, converges with the phylogenetic and ontogenetic concepts of normal and abnormal growth of bone in limbs and cranio-facial development suggests that a combination of correlation and epigenetic analysis would be helpful in establishing a sound genetic background for the newer biomechanic, functional matrix and architectonic approaches.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Hoboken, NJ [u.a.] : Wiley-Blackwell
    Journal of Orthopaedic Research 2 (1984), S. 161-168 
    ISSN: 0736-0266
    Keywords: Rabbit ; Spondylosis ; Calcified nucleus pulposus ; Intervertebral disc degeneration ; Life and Medical Sciences
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The spines of 35 rabbits (32 New Zealand white and 3 AC/J), ranging in age from 3 months to 8½ years, were investigated systematically for spontaneous degenerative changes. Three types of lesion were observed. (1) The nucleus pulposus underwent chondroid metaplasia throughout the length of the vertebral column by the age of 2 years. (2) Hydroxyapatite deposition was found in the nucleus pulposus in 12 of 20 animals examined roentgenographically. The lesion occurred principally in the distal thoracic segments and was first observed in 3-month-old rabbits. (3) Spondylosis occurred in each of four macerated spines from animals 〉24 months old. Portions of the spine spared by disc calcification were affected.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
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