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  • 1
    Electronic Resource
    Electronic Resource
    Homoeosis in Drosophila: Maternal effect of the enhancer of Polycomb locus and its interaction with Polycomb and related loci (1983)
    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 4 (1983), S. 185-198 
    Details
    ISSN: 0192-253X
    Keywords: maternal effects ; Polycomb locus ; Drosophila ; homoeosis ; Enhancer of Polycomb ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: A mutation or deficiency of the Enhancer of Polycomb (E(Pc)) locus acts as a dominant enhancer of the adult mutant phenotypes of a group of similar homoeotic loci (Polycomb, Polycomblike, extra sex comb, and lethal(4)29). The E(Pc) mutation has a recessive lethal effect, and homo- and hemizygotes die as late embryos or larvae which appear cuticularly normal. E(Pc) also acts as a dominant enhancer of the embryonic homoeotic syndromes associated with Polycomb. Polycomblike, and lethal(4)29 mutations: its effect on the extra sex comb syndrome has not been effectively evaluated. At least for the interaction with Polycomb mutations, evidence is presented that the Enhancer of Polycomb locus has a maternal as well as a zygotic effect, and that its effect on Polycomb expression is not at the level of transcription. We suggest that the Enhancer of Polycomb locus acts specifically to regulate the activities of this set of homoeotic loci, and that E(Pc) recessive lethality results from noncuticular homoeotic defects which arise as a consequence of their reduced activity. In the context of this hypothesis, no present data allow us to distinguish whether Enhancer of Polycomb is a nonhomoeotic locus regulating the function(s) of Polycomb and related genes or is itself a homoeotic locus.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/dvg.1020040305
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  • 2
    Electronic Resource
    Electronic Resource
    Embryonic expression of the single Tribolium engrailed homolog (1994)
    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 15 (1994), S. 7-18 
    Details
    ISSN: 0192-253X
    Keywords: Tribolium ; engrailed ; embryogenesis ; segmentation ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: We have cloned and sequenced the single Tribolium homolog of the Drosophila engrailed gene. The predicted protein contains a homeobox and several domains conserved among all engrailed genes identified to date. In addition it contains several features specific to the invected homologs of Bombyx and Drosophila, indicating that these features most likely were present in the ancestral gene in the common ancestor of holometabolous insects. We used the cross-reacting monoclonal antibody, 4D9, to follow the expression of the Engrailed protein during segmentation in Tribolium embryos. As in other insects, Engrailed accumulates in the nuclei of cells along the posterior margin of each segment. The first Engrailed stripe appears as the embryonic rudiment condenses. Then as the rudiment elongates into a germ band, Engrailed stripes appear in an anterior to posterior progression, just prior to morphological evidence of the formation of each segment. As in Drosophila (a long germ insect), expression of engrailed in Tribolium (classified as a short germ insect) is preceeded by the expression of several homologous segmentation genes, suggesting that similar genetic regulatory mechanisms are shared by diverse developmental types. © 1994 Wiley-Liss, Inc.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/dvg.1020150103
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  • 3
    Electronic Resource
    Electronic Resource
    Structure and function of the homeotic gene complex (HOM-C) in the beetle, Tribolium castaneum (1993)
    New York, NY : Wiley-Blackwell
    BioEssays 15 (1993), S. 439-444 
    Details
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The powerful combination of genetic, developmental and molecular approaches possible with the fruit fly, Drosophila melanogaster, has led to a profound understanding of the genetic control of early developmental events. However, Drosophila is a highly specialized long germ insect, and the mechanisms controlling its early development may not be typical of insects or Arthropods in general. The beetle, Tribolium castaneum, offers a similar opportunity to integrate high resolution genetic analysis with the developmental/molecular approaches currently used in other organisms. Early results document significant differences between insect orders in the functions of genes responsible for establishing developmental commitments.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bies.950150702
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  • 4
    Electronic Resource
    Electronic Resource
    Lethal(1)aberrant immune response mutations leading to melanotic tumor formation in Drosophila melanogaster (1991)
    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 12 (1991), S. 173-187 
    Details
    ISSN: 0192-253X
    Keywords: Melanotic tumor mutations ; cellular defense system ; invertebrate immunity ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Using P element-mediated mutagenesis we have isolated 20 X-linked lethal mutations, representing at least 14 complementation groups, which exhibit melanotic tumor phenotypes. We present the systematic analysis of this interesting group of lethal mutations that were selected for their visible melanotic or immune response. The lethal and melanotic tumor phenotypes of each lethal(1) aberrant immune response (air) mutation are pleiotropic effects of single genetic lesions. Lethality occurs throughout the larval and early pupal periods of development and larval development is extended in some air mutants. The air mutant lethal syndromes include abnormalities associated with the brain, haematopoietic organs, gut, salivary glands, ring glands, and imaginal discs. Additional characterization of the melanotic tumor mutations Tuml and tu(1)Szts have indicated that the melanotic tumor phenotype is similar to that observed in the air mutants. These studies have led to the proposal that two distinct classes of melanotic tumor mutations exist. Class 1 includes mutants in which melanotic tumors result from “autoimmune responses” or the response of an apparently normal immune system to the presence of abnormal target tissues. The Class 2 mutants display obvious defects in the haematopoietic organs or haemocytes, manifested as overgrowth, and the resulting aberrant immune system behavior may contribute to melanotic tumor formation.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/dvg.1020120302
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