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  • 1
    Electronic Resource
    Electronic Resource
    The effect of lithium on 5-HT-mediated neuroendocrine responses and platelet 5-HT receptors (1986)
    Springer
    Psychopharmacology 90 (1986), S. 398-402 
    Details
    ISSN: 1432-2072
    Keywords: Lithium ; Tryptophan ; Prolactin ; Growth hormone ; 5-HT receptors ; Imipramine binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of lithium on serotonin (5-HT)-mediated responses in the brain was assessed by measuring changes in the prolactin (PRL) and growth hormone (GH) responses to l-tryptophan (LTP) in eight normal subjects. On the 4th day of lithium treatment the PRL responses were significantly enhanced, and this enhancement was still apparent after 20 days' treatment. In contrast, GH responses to LTP were not altered. Lithium had no effect on platelet 5-HT content, platelet imipramine binding and platelet 5-HT receptor binding. The ability of lithium to enhance some aspects of brain 5-HT function may be important in its mode of action in manic-depressive illness and may be particularly relevant to its potentiation of the antidepressant effect of tricyclic antidepressants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00179198
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    5-HT1A receptors in lithium-induced conditioned taste aversion (1997)
    Springer
    Psychopharmacology 133 (1997), S. 51-54 
    Details
    ISSN: 1432-2072
    Keywords: Key words Conditioned taste aversion ; Lithium ; Serotonin ; 5-HT1A receptor ; 8-OH-DPAT ; Pindolol ; p-MPPI ; PCPA ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Experiments were carried out using rats to investigate whether 5-HT1A neural mechanisms are involved in lithium-induced conditioned taste aversion (CTA). We found that the 5-HT1A antagonists p-MPPI and pindolol caused CTA similar to that produced by LiCl. The 5-HT1A agonist 8-OH-DPAT counteracted lithium-induced CTA. Pindolol dose-dependently abolished effects of 8-OH-DPAT on LiCl-induced CTA. These findings support the notion that lithium has antagonistic actions on 5-HT1A receptors. Inhibition of 5-HT synthesis by PCPA failed, however, to prevent lithium-induced CTA. Evidently, mechanisms other than those governed solely by 5-HT are also involved in lithium-induced CTA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130050370
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Lithium alters the stereoselectivity of monoamine oxidase in rat brain (1989)
    Springer
    Journal of neural transmission 76 (1989), S. 205-210 
    Details
    ISSN: 1435-1463
    Keywords: Lithium ; monoamine oxidase ; phenylethylamine ; serotonin ; tranylcypromine enantiomers ; stereoselective index
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of lithium on monoamine oxidase (MAO) in rat brain were studied in the presence of each enantiomer of tranylcypromine [(+)- and (−)-TCP]. The (+)-enantiomer was 25 times more potent than its antipode as MAO inhibitor. Lithium enhanced the inhibitory effect of (−)-TCP on MAO, but it did not affect actions of the (+)-enantiomer. Moreover, lithium influenced the stereo selective index for MAO, which suggests that lithium altered conformational features of the enzyme.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01260505
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    Paper (German National Licenses)
    Fulltext
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