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  • 1
    Electronic Resource
    Electronic Resource
    Platelet and lymphocyte free intracellular calcium in affective disorders (1994)
    Springer
    European archives of psychiatry and clinical neuroscience 243 (1994), S. 235-239 
    Details
    ISSN: 1433-8491
    Keywords: Intracellular calcium ; Affective disease ; Platelets ; Lymphocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Many studies have demonstrated pharmacologic similarities between platelet and brain 5-HT2 binding sites. Therefore it may be possible to use platelets as a model for the central serotonergic neuron. Accordingly, a previcus report (Kusumi et al. 1991b) about elevated [Ca2+]i after serotonin stimulation in platelets of depressed patients was interpreted as further evidence for enhanced serotonergic sensitivity in depression. However, a very recent study showed an enhanced thrombin-induced platelet Ca2+ response, rather suggesting abnormalities of intracellular Ca2+ regulation in affective disorders. In the present study we have determined 5-HT2-and thrombin-induced Ca2+ responses in platelets and additionally phytohemagglutin (PHA)-induced Ca2+ increase in lymphocytes of medicated depressed patients (8 mono- and 2 bipolar, HRSD〉17) and of ten sex- and age-matched controls. The results showed no significant difference in basal calcium levels between the two groups and no significant difference in the Ca2+ response to thrombin although the response was higher in the patients. The Ca2+ increase after serotonin stimulation in depressed patients was significantly (P〈0.05) higher than in healthy controls. By contrast, the Ca2+ response to PHA in lymphocytes was significantly decreased in the patients. Our data confirm elevated Ca2+ responses after 5-HT2 receptor activation even in medicated depressed patients. However, Ca2+ responses in lymphocytes were decreased. Together with the observations of an enhanced Ca2+ response in platelets after thrombin stimulation, we speculate that the findings rather suggest alterations of [Ca2]i regulation in depression than specific changes of serotonergic sensitivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02191580
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  • 2
    Electronic Resource
    Electronic Resource
    Therapeutic concentrations of lithium and carbamazepine inhibit cGMP accumulation in human lymphocytes (1991)
    Springer
    Psychopharmacology 104 (1991), S. 45-50 
    Details
    ISSN: 1432-2072
    Keywords: Lithium ; Carbamazepine ; Guanylate cyclase ; Lymphocytes ; Mechanism of action
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Although a large variety of biochemical effects have been reported for lithium (Li) and carbamazepine (Cbm), the final molecular mechanism underlying their therapeutic efficacy for recurrent affective disorders is still unknown. The data presented here clearly indicate that therapeutic concentrations of both drugs inhibit sodium nitroprusside-induced accumulation of cGMP in human lymphocytes to about the same extent. The effect is not seen for other antidepressants, and shows pronounced interindividual variations in healthy volunteers. A similar effect of lithium and carbamazepine can also be demonstrated for the cGMP accumulation of central neurons using the model of dissociated cells of the mouse brain. The results are discussed in view of a common mechanism of action of both drugs. Furthermore, it is speculated that the individual sensitivity of the cGMP generating system of human lymphocytes to both drugs might be used to predict therapeutic response or nonresponse of the individual patient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02244552
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The effect of intravenous cyclophosphamide pulse on peripheral blood lymphocytes in lupus erythematosus patients (1997)
    Springer
    Rheumatology international 17 (1997), S. 55-60 
    Details
    ISSN: 1437-160X
    Keywords: Key words Lupus erythematosus ; Cyclophosphamide ; Lymphocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the present study we investigated the long-term effect of intravenous pulse cyclophosphamide (CY) on lymphocyte surface antigens in systemic lupus erythematosus (SLE) patients. Blood samples derived from 17 lupus erythematosus patients were analysed using two- and three-colour flow cytometry. During the CY therapy, the total number of T lymphocytes (CD3+) was reduced by 31.4%, B lymphocytes (CD19+) by 67.4% and NK cells (CD16+) by 27.4%. Six months after the end of the CY regimen, these values recovered to entry levels. At the onset of the study we observed increased percentages of CD3+ CD25+, CD3+ CD4– CD8–, CD4+ CD29+, CD19+ and CD19+ CD5+ cells. The CY treatment regimen decreased the CD3+ CD25+, CD3+ CD4– CD8–, CD19+ and CD19+ CD5+ cells, but increased the CD3+ CD8+ subpopulation. Taken together, a deficiency of CD8+ T cells associated with CD4+ CD29+ predominance may imply an immune regulatory imbalance leading to abnormal CD4+ cell activation and in consequence to autoimmunity. Depletion of CD19+ cells combined with an enlargement of CD8 cells as a result of CY therapy may reduce the enhanced immune response in SLE patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00006852
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    Paper (German National Licenses)
    Fulltext
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