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  • 1
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Schizophrenie ; Magnetencephalographie ; Akustisch-evozierte Felder ; Geschlechtsunterschiede ; Hemisphärenasymmetrie ; Key words Schizophrenia ; Magnetoencephalography ; Acoustically evoked fields ; Gender differences ; Hemispheric asymmetry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In this magnetoencephalography study the issue of hemispheric lateralisation in patients with schizophrenia was addressed using acoustically evoked neuromagnetic fields. The characteristics of dipoles in the superior temporal gyrus, the primary auditory cortex, were calculated. In contrast to other studies, alterations did not concern the localisation, but rather the orientation of dipoles. Of pathophysiological interest was that the dipoles abnormalities were found left-hemispherically in male (p=0.02) and right-hemispherically in female patients with schizophrenia (p=0.01) when compared to controls. The findings suggest gender-specific alterations of hemispheric lateralisation in schizophrenia.
    Notes: Zusammenfassung In dieser Magnetenzephalographiestudie wurde die Frage der Hemisphärenlateralisation bei Patienten mit einer Schizophrenie mittels akustisch evozierter neuromagnetischer Felder untersucht und die Charakteristika von Dipolen berechnet, die im Bereich des Gyrus temporalis superior, dem primären Hörkortex, entstehen. Im Gegensatz zu Vorbefunden betrafen die Alterationen weniger die Dipollokalisation als vielmehr die Dipolorientierung. Pathophysiologisch aufschlußreich war, daß die Dipolabweichungen im Vergleich zu Kontrollen bei männlichen Schizophrenen linkshemisphärisch (p=0,02), bei weiblichen Schizophrenen rechtshemisphärisch (p=0,01) nachweisbar waren. Dieses Ergebnis spricht für geschlechtsspezifische Unterschiede der Hemisphärenlateralisation bei Schizophrenien.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1084
    Keywords: Becker dystrophy ; Duchenne dystrophy ; High-energy phosphates ; 31P MR spectroscopy ; Principal component analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A total of 14 boys with the Duchenne and Becker forms of muscular dystrophy (DMD, BMD) were examined using 31P magnetic resonance (MR) spectroscopy; 12 boys were examined repeatedly. The results were correlated with clinical findings (including those of genetic tests) and with data obtained from examinations of an age-matched control group. Evaluation of results using principal component analysis revealed maximum variability in the following ratios: phosphocreatine/inorganic phosphate (PCr/Pi), phosphocreatine/phosphodiesters (PCr/PDe) and phosphocreatine/phosphomonoesters (PCr/PMe). A decrease in PCr/Pi correlates with weakness of the hip girdle and of the lower part of the shoulder girdle in DMD/BMD patients. The values of all ratios in the group of patients with the DMD phenotype differ significantly from results obtained in the group with the BMD phenotype. Continoous follow-up of patients using 31P MR spectroscopy revealed a marked decrease in PCr/Pi in DMD/BMD patients at an age that could be expected in subjects with a typical clinical course of DMD/BMD. An attempt to manage a concomitant disease with prednisone and carnitene was followed by an increase in PCr/Pi in 3 cases. A rise in the PCr/Pi ratio signalled clinical improvement in the patients. A decrease in PCr/Pi was found after controlled physical training, a finding consistent with data obtained from clinical observations describing an adverse effect of physical stress on the dystrophic process.
    Type of Medium: Electronic Resource
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