ISSN:
1432-2307
Keywords:
IgA-Nephropathy
;
Focal glomerulonephritis
;
Mesangioproliferative glomerulonephritis
;
Mesangium
;
Hematuria
;
Immunohistology
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary From 166 renal biopsies of 153 patients who showed the dominating mesangial IgA deposits of “IgA-Nephropathy”, relationships were established between immunohistologic, histologic and clinical findings with the following results: 1. The immunohistologic picture of IgA-Nephropathy exhibits a broad histologic spectrum including cases with histologically normal findings as well as mesangioproliferative Gn with focal and diffuse crescents. Most often the morphologic changes are associated with a mild and moderately severe mesangioproliferative Gn. 2. According to the extent of the morphologic lesions no discrepancy between immunohistologic and histologic findings exists. Excluding a few cases with a focal accentuation of the histologic picture the histologic lesions as well as the immunofluorescence pattern are diffuse. 3. The immunohistologic picture of IgA-Nephropathy cannot be associated with uniform and characteristic clinical and morphologic pictures. Therefore, the predominant mesangial IgA deposits of the IgA-Nephropathy-type should not be regarded as a clinical — morphologic entity but rather as a specific immunohistologic symptom with possible different underlying pathomechanisms, probably controlled by a common genetically determined aberrant immune response with in consequence various morphologic reactions of different intensity and with a relatively favorable prognosis in most cases.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00433537
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