ISSN:
1432-2307
Keywords:
Cathepsin B
;
Basement membrane
;
Type IV collagen
;
Metastasis
;
Lung adenocarcinoma
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The distributions of cathepsin B (CB) a lysosomal cysteine proteinase, type IV collagen (CIV) and laminin (LM), which are main components of basement membranes (BMs) were studied in a series of 64 human lung adenocarcinomas using an immunohistochemical technique. Over-expression of CB (〉80% positive cells) was significantly associated with the grade of tumour differentiation (p〈0.01), with lymph node metastasis (p〈0.01) and with BM degradation (p〈0.01) detected by the staining pattern of CIV and LM. It was significantly associated with a prognostic disadvantage (p〈0.01). The immunohistochemical staining pattern of CB has a close relationship with degradation of BM, and may be used as a marker for tumour metastasis and prognosis in lung adenocarcinoma.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00197390
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