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  • 1
    Electronic Resource
    Electronic Resource
    Responses of the photosynthetic flagellate, Euglena gracilis, to hypergravity (1991)
    Springer
    European biophysics journal 20 (1991), S. 101-107 
    Details
    ISSN: 1432-1017
    Keywords: Euglena gracilis ; Gravitaxis ; Image analysis ; Microgravity ; NIZEMI (slow rotating centrifuge microscope) ; Velocity of movement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract Motility and orientation has been studied in the unicellular photosynthetic flagellate, Euglena gracilis, using real time image analysis capable of tracking up to 200 cells simultaneously in the slow rotating centrifuge microscope (NIZEMI) which allows one to observe the cells' swimming behavior during centrifugation accelerations between 1 g and 5 g. At 1 g the cells show a weak negative gravitaxis, which increases significantly at higher accelerations up to about 3 g. Though most cells were capable of swimming even against an acceleration of 4.5 g, the degree of gravitaxis decreased and some of the cells were passively moved downward by the acceleration force; this is true for most cells at 5 g. The velocity of cells swimming against 1 g is about 10% lower than that of cells swimming in other directions. The velocity decreases even more drastically in cells swimming against higher acceleration forces than those at 1 g. The degree of gravitactic orientation drastically decreases after short exposure to artificial UV radiation which indicates that gravitaxis may be due to an active physiological perception rather than a physical effect such as an asymmetry of the center of gravity within the cell.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00186258
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of dopamine infusion on plasma catecholamines in preterm and term newborn infants (1991)
    Springer
    European journal of pediatrics 150 (1991), S. 503-506 
    Details
    ISSN: 1432-1076
    Keywords: Dopamine infusion ; Newborn infants ; Plasma catecholamines ; Noradrenaline ; Adrenaline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Newborn infants (21 preterm and 13 term) received dopamine infusions at a low (2.5–3.4 μg/kg per min) and/or high (5–10 μg/kg per min) infusion rate and changes in plasma catecholamines were monitored. The mean baseline values for dopamine, noradrenaline and adrenaline were between 240 and 560, 125 and 144 and 62 and 82 pg/ml, respectively. During low-rate infusion of dopamine, there was a significant increase in plasma dopamine (20–100fold), noradrenaline (three- to five-fold) and adrenaline (threefold). Administration of dopamine at the high rate resulted in an even larger increase in the plasma catecholamines (dopamine, 100–300fold; noradrenaline, seven- to eightfold; adrenaline, four- to sixfold). In a double-log plot, there was a highly significant correlation between the plasma concentrations of dopamine and noradrenaline (r=0.77;P〈0.001). In conclusion, infusion of dopamine in term and preterm newborn infants is accompanied by an enhanced sympatho-adrenal tone which may contribute to the cardiovascular effects of dopamine in these patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01958433
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Continuous monitoring of mixed venous oxygen saturation in infants after cardiac surgery (1989)
    Springer
    Intensive care medicine 15 (1989), S. 228-232 
    Details
    ISSN: 1432-1238
    Keywords: Infants ; Continuous SvO2 ; Cardiac surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Continuous mixed venous oxygen saturation SvO2c was measured in 16 infants immediately after cardiac surgery. A polyurethane 4F, dual channel catheter (Opticath, Modell U440, Oximetrix) with fiberoptic filaments was introduced into the pulmonary artery during cardiothoracic surgery. The catheters were left in place for an average of 67.5 h (range 27 h – 125 h) and there were no catheter-related complications. Correlation between continuous in vivo SvO2 values and in vitro values was satisfactory (r=0.85), whereas a correlation between SvO2c and arterial oxygen saturation (SaO2) was not found (r=0.07). The sampled arterial lactate values were inversely correlated to the simultaneously measured SvO2c, but the corelation coefficient was only r=-0.4. There was an inverse correlation between SvO2c and arteriovenous oxygen content difference (Ca−vDO2c) (r=-0.82), and a marked inverse correlation to the calculated oxygen utilization ratio (r=-0.97). Therefore SvO2c continuously reflects the overall balance between oxygen consumption and delivery, but the use of SvO2 as a predictor of blood lactate levels is unreliable. A further purpose of the present study was to demonstrate the clinical applications and to show the usefulness of SvO2c-monitoring; particularly as a surveillance and early warning system, as a guide for assessing therapy and its relevance in interpreting other monitored parameters. In our opinion continuous SvO2 measurement is a reliable and valuable indicator of cardiopulmonary function in the immediate post-operative period, even in infants with complicated repair of cardiac malformations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00271056
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    Paper (German National Licenses)
    Fulltext
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