Bibliothek

feed icon rss

Ihre E-Mail wurde erfolgreich gesendet. Bitte prüfen Sie Ihren Maileingang.

Leider ist ein Fehler beim E-Mail-Versand aufgetreten. Bitte versuchen Sie es erneut.

Vorgang fortführen?

Exportieren
Filter
  • Interferon  (2)
  • Drinking Patterns for Alcohol  (1)
  • Miscellaneous Medical  (1)
  • 1
    ISSN: 1432-0843
    Schlagwort(e): 5-Fluorouracil ; Interferon ; Colorectal cancer
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Modulation of 5-fluorouracil (FUra) using leucovorin (LV) is a standard treatment approach in patients with metastatic colorectal cancer. Modulation of FUra with interferon alfa has also shown some promise. Laboratory data have demonstrated increased cytotoxicity when FUra is combined with both LV and interferon. The current study examined the effects of double modulation of FUra using LV and interferon. Patients with measurable advanced colorectal cancer received bolus FUra 375 mg/m2 plus LV 20 mg/m2 daily for 5 days, repeated every 28 days. Recombinant human interferon alfa-2a, 3 million IU/m2 subcutaneously, was given daily on the days of chemotherapy then three times weekly. There was one complete response and nine partial responses (10/41) seen for an overall response rate of 24% (95% CI 12.0–40.0%). Overall, 70% of patients experienced one or more episodes of nonhematologic toxicity of grade 3 or more. Weight loss was common, with a mean decrease of 2.9 kg over the first two months (P〈0.0001). Improvements in tumor-related symptoms were balanced by increased fatigue and a deterioration in body weight and performance status. There was no evidence of progressive changes in FUra metabolism from interferon usage.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 2
    ISSN: 1432-0843
    Schlagwort(e): Key words 5-Fluorouracil ; Interferon ; Colorectal cancer
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  Modulation of 5-fluorouracil (FUra) using leucovorin (LV) is a standard treatment approach in patients with metastatic colorectal cancer. Modulation of FUra with interferon alfa has also shown some promise. Laboratory data have demonstrated increased cytotoxicity when FUra is combined with both LV and interferon. The current study examined the effects of double modulation of FUra using LV and interferon.Patients with measurable advanced colorectal cancer received bolus FUra 375 mg/m2 plus LV 20 mg/m2 daily for 5 days, repeated every 28 days. Recombinant human interferon alfa-2a, 3 million IU/m2 subcutaneously, was given daily on the days of chemotherapy then three times weekly. There was one complete response and nine partial responses (10/41) seen for an overall response rate of 24% (95% CI 12.0–40.0%). Overall, 70% of patients experienced one or more episodes of nonhematologic toxicity of grade 3 or more. Weight loss was common, with a mean decrease of 2.9 kg over the first two months (P〈0.0001). Improvements in tumor-related symptoms were balanced by increased fatigue and a deterioration in body weight and performance status. There was no evidence of progressive changes in FUra metabolism from interferon usage.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 3
    Digitale Medien
    Digitale Medien
    Springer
    Psychopharmacology 15 (1969), S. 361-372 
    ISSN: 1432-2072
    Schlagwort(e): Alcohol Preference ; Ethanol Intake ; Fluid Intake ; Drinking Patterns for Alcohol ; Tolerance to Ethyl Alcohol
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary When offered water and different solutions of ethyl alcohol in a freechoice situation, naive rats prefer alcohol at low concentrations but reject alcohol as the concentrations are increased sequentially. Rats which were either group or individually housed and forced to drink a non-preferred 12 or 15 per cent alcohol solution, drank less alcohol than control animals in a subsequent free-choice test. On the other hand, the animals that were repeatedly exposed to 11-day periods during which the concentrations of alcohol were systematically increased from 3 to 30 per cent consumed two to three times more alcohol in the seventh sequence than in the first sequence. In the free-choice situation this acclimation effect occurred when water was constantly present. This method appears to be useful for inducing animals to consume large volumes of ethyl alcohol.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 4
    Digitale Medien
    Digitale Medien
    New York, NY [u.a.] : Wiley-Blackwell
    Clinical Anatomy 7 (1994), S. 115-124 
    ISSN: 0897-3806
    Schlagwort(e): urinary extravasation ; proposed terminology ; Life and Medical Sciences ; Miscellaneous Medical
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: The fascias of the male external genitalia and perineum serve as surgical landmarks and are considered to act as initial barriers to urinary extravasation; thus they are of fundamental importance to the urologist and anatomist. There is little agreement, however, about the naming and function of these fascias because they have been defined inconsistently. The extensive use of eponyms for the fascias adds even further confusion to the proper nomenclature. Our findings, based upon dissection and magnetic resonance imaging (MRI), show that except for the single layer of dartos (smooth muscle) in the scrotum, there are two distinct layers of fascia in the penis and perineum that are continuous with each other and the anterior wall fascias. To minimize confusion, we conclude that the fascial layrs around the penis be termed the superficial and deep penile fascias, and those to which they are continuous in the perineum be termed the membranous layer of the superficial perineal fascia (the fibrous stratum that traverses the superficial fascia) and the deep perineal fascia. Their presumed role in limiting urinary extravasation is based upon relatively few well-detailed report and currently remains poorly understood. However, this may be improved upon in the future through combined application of clinical findings and MRI to individual cases of urinary extravasation. © 1994 Wiley-Liss, Inc.
    Zusätzliches Material: 7 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
Schließen ⊗
Diese Webseite nutzt Cookies und das Analyse-Tool Matomo. Weitere Informationen finden Sie hier...