ISSN:
1432-0584
Keywords:
Bone marrow plasmocytosis
;
Monoclonal plasma cells
;
Polyclonal plasma cells
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Bone-marrow biopsies and smears from 59 patients with reactive plas-mocytosis (22), multiple myeloma (24), solitary plasmocytoma (3) and monoclonal gammopathy of undetermined significance (MGUS) (10) were eamined. To demonstrate cytoplasmic immunoglobulin the immunoperoxidase method was applied and evaluated quantitatively. Immunohistology yielded different ranges in κ/λ ratio for reactive plasmocytosis (0.4–3.5), multiple myeloma (≤ 0.1 and ≥ 11.2) and MGUS (0.2–3.0). As a result this method seems to be helpful in characterizing a plasmocytosis and distinguishing overt myeloma from monoclonal gammopathy of undetermined significance and reactive plasmocytosis. A differentiation of monoclonal gammopathy of undetermined significance from reactive plasmocytosis is not possible histologically and immunohistologically.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00320578
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