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  • 1
    Electronic Resource
    Electronic Resource
    Acute inflammatory demyelinating polyneuropathy in a diabetic patient: Predominance of vesicular disruption in myelin sheaths (1985)
    Springer
    Acta neuropathologica 67 (1985), S. 337-340 
    Details
    ISSN: 1432-0533
    Keywords: Diabetes mellitus ; Myelin ; Peripheral nerve ; Polyradiculoneuropathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A diabetic woman underwent an incision of the right big toe for an abscess and developed a typical Guillain-Barré syndrome 48 h later. A biopsy of a peripheral nerve, performed 10 days later, showed modifications usually seen in diabetic patients, as well as the characteristic ultrastructural modifications of the Guillain-Barré syndrome (GBS). Moreover, 22% of myelinated fibers exhibited vesicular disruption of the myelin sheaths. This lesion is rarely encountered on the biopsies of peripheral nerve in GBS and concerns only a few myelinated fibers. Such a prominence of myelinic vesicular disruption and its occurrence in a diabetic patient are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687823
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  • 2
    Electronic Resource
    Electronic Resource
    Variability of morphological features in early infantile polyneuropathy with defective myelination (1987)
    Springer
    Acta neuropathologica 73 (1987), S. 295-300 
    Details
    ISSN: 1432-0533
    Keywords: Axon ; Myelin ; Infantile polyneuropathy ; Peripheral nerve ; Schwann cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Four cases of early infantile polyneuropathy with defective myelination are reported. The peripheral nerve was studied by light and electron microscopy; different morphological characteristics have been noticed in these patients. Case 1 presented aspects of defective myelination with atypical “onion bulb” formation composed of multiple layers of basement membrane. In case 2, defective myelination and atypical “onion bulb” formation were associated with aberrant hypermyelination. Cases 3 and 4 were brothers, who presented axonal damage and atypical “onion bulb” formation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686625
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Polyneuropathy associated with IgM monoclonal gammopathy (1989)
    Springer
    Acta neuropathologica 79 (1989), S. 160-167 
    Details
    ISSN: 1432-0533
    Keywords: Dysglobulinemia ; Myelin ; Myelin-associated glycoprotein ; Polyneuropathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Quantitative, immunopathological, light and electron microscopic studies of superficial peroneal nerve biopsies from 31 patients with IgM monoclonal gammopathy were carried out. Six patients had Waldenström's macroglobulinemia and 25 had IgM monoclonal gammopathy of undetermined significance. Serum samples from 28 of these patients were assayed for anti-myelin-associated glycoprotein (anti-MAG) activity. Anti-MAG activity was found in 25 of the samples. There was a relationship between the widening of some myelin lamellae observed on ultrastructural examination and the serum anti-MAG activity (23 cases). Immunopathological examination showed IgM binding to myelin sheaths in 17 cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294374
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Polyarteritis nodosa and peripheral neuropathy (1985)
    Springer
    Acta neuropathologica 67 (1985), S. 136-141 
    Details
    ISSN: 1432-0533
    Keywords: Axon ; Myelin ; Peripheral nerve ; Polyarteritis nodosa
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Peripheral nerves from 13 patients suffering from polyarteritis nodosa with multiple mononeuropathy were studied by light and electron microscopy. In the majority of cases, the vascular lesions were associated with Wallerian-like degeneration. Myelinated fibers presenting a normal axon with a disproportionately thin myelin sheath were less numerous. Unusual abnormalities consisted of swollen axons with an accumulation of organelles. Unmyelinated fibers were also damaged. A quantitative estimation of myelinated fibers loss did not show any selective vulnerability of either the large or the small diameter group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688134
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Uncompacted myelin lamellae in polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes syndrome (1994)
    Springer
    Acta neuropathologica 87 (1994), S. 302-307 
    Details
    ISSN: 1432-0533
    Keywords: Castleman disease ; Monoclonal gammopathy ; Myelin ; Peripheral neuropathy ; POEMS syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Mechanisms of peripheral neuropathies in polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes (POEMS) syndrome are poorly understood. A peripheral nerve biopsy was performed in 22 patients. Of these 9 had histological features of Castleman's disease on lymph node biopsies, and 19 had a monoclonal lambda light chain in their serum. Certain nerve fragments were paraffin embedded, others were frozen and studied by direct immuno-fluorescence, and others were fixed for ultrastructural examination. Paraffin-embedded fragments did not show any amyloid deposits, and at direct immunofluorescence there was no immunoglobulin fixation. At ultrastructural examination, features of uncompacted myelin lamellae (UML) were present in 19 patients, and their frequency varied from 1% to 16% of myelinated fibres. Up to now UML have been reported only in 7 patients with POEMS syndrome in the literature. UML have also been noticed in a few cases of inflammatory demyelinating polyradiculoneuritis and inherited tendency to pressure palsy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00296746
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  • 6
    Electronic Resource
    Electronic Resource
    Relapsing inflammatory demyelinating polyneuropathy in a diabetic patient (1986)
    Springer
    Acta neuropathologica 71 (1986), S. 94-99 
    Details
    ISSN: 1432-0533
    Keywords: Diabetes mellitus ; Guillain-Barré syndrome ; Myelin ; Polyneuropathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Inflammatory demyelinating polyradiculoneuropathies exhibit well-known ultrastructural lesions of the peripheral nerve, both in acute cases, i.e., Guillain-Barré syndrome, and in relapsing, subacute and chronic cases. We present a case of relapsing inflammatory demyelinating polyradiculoneuropathy in a diabetic patient with a biopsy exhibiting these lesions, as well as a widening of the outermost myelin lamellae in some fibers. Such associated lesions are classic in experimental inflammatory demyelinating polyradiculoneuropathies, but have not been reported in human pathology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687968
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Congenital hypomyelination with axonopathy (1989)
    Springer
    European journal of pediatrics 148 (1989), S. 470-472 
    Details
    ISSN: 1432-1076
    Keywords: Axonopathy ; Congenital neuropathy ; Myelin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report a case of congenital neuropathy taking a rapidly fatal clinical course. Ultrastructural features of the peripheral nerve were unusual with sparsity of myelinated fibres, lack of “onion bulb” formation and presence of axonal damage. This case is compared with previously reported cases of early infantile neuropathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00595918
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  • 8
    Electronic Resource
    Electronic Resource
    Peripheral neuropathies and lymphoma without monoclonal gammopathy: a new classification (1990)
    Springer
    Journal of neurology 237 (1990), S. 177-185 
    Details
    ISSN: 1432-1459
    Keywords: Axon ; Lymphoma ; Myelin ; Peripheral neuropathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Recent progress in immunopathological studies of peripheral nerve and lymph node fragments together with 16 personal cases and numerous clinicopathological reports have suggested a new classification of peripheral neuropathies (PN) and lymphomas. These are: (1) PN due to local infiltrations by a T-cell lymphoma; (2) acute polyradiculoneuritis due to active demyelination and associated with infiltrates of a T-cell lymphoma in the epineurium, resembling Marek's disease (which is a T-cell lymphoma); (3) B-cell lymphoma proliferation which may be restricted to or predominate in the peripheral nervous system, with a large clinicopathological heterogeneity ranging from localized forms to ascending polyradiculoneuropathies; (4) angiotropic lymphoma, which is a B-cell lymphoma and may present as an acute mononeuropathy; (5) patients with acquired immunodeficiency syndrome due to lymphomatous infiltrates in the endoneurium, of which 2 cases of PN have been reported; (6) PN associated with organomegaly, endocrinopathy, M-component and skin lesions, certain cases being associated with a plasmocytoma and sometimes Castleman's disease but without any monoclonal gammopathy; (7) classic Guillain-Barré syndrome, prone to develop in patients with extraneural lymphoma but without any lymphomatous infiltrates in the peripheral nervous system; (8) certain cases (4 out of 16 in our series) where there is no clear relationship between PN and lymphoma, and there are mainly features of axonal degeneration. Inflammatory perivascular infiltrates were sometimes present in the epineurium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314591
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