ISSN:
1619-7089
Keywords:
Dilated cardiomyopathy (DCM)
;
Myocardial scintigraphy
;
123I-Metaiodobenzylguanidine (MIBG)
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Serial change of the metaiodobenzylguanidine iodine-123 (123I-MIBG) myocardial concentration was investigated in patients with dilated cardiomyopathy (DCM). Eight DCM patients and 6 control subjects were examined. After the injection of thallium-201 and 123I-MIBG, planar chest images were obtained simultaneously for both tracers in every 30–60 min over 5 h. Serial changes of myocardial uptake ratio (MUR) were compared for both tracers. In DCM, the initial MUR of 123I-MIBG did not differ significantly from that of the controls. The washout of 123I-MIBG from the myocardium, however, was significantly increased in DCM. In particular, the decrease in the early phase (15–45 min) was significantly larger in DCM than in the controls (21.2%±7.5% vs. 5.3%±4.0%, P 〈0.01), showing a significant negative correlation with the left ventricular ejection fraction (r = −0.72 P 〈 0.05). For 201TI, neither the initial MUR nor the washout rate different significantly between the two. Thus, an early rapid decrease of the 123I-MIBG myocardial concentration might characterize DCM and reflect the severity of this disease.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00175140
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