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  • Fluorometric analysis  (1)
  • Myopathy  (1)
  • Styrene  (1)
  • 1
    Digitale Medien
    Digitale Medien
    The free erythrocyte protoporphyrin assay in monitoring lead-exposed workers (1980)
    Springer
    International archives of occupational and environmental health 45 (1980), S. 35-48 
    Details
    ISSN: 1432-1246
    Schlagwort(e): Lead intoxication ; Free erythrocyte protoporphyrin ; Fluorometric analysis ; Hematofluorometer
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary We have performed a comparative analysis of two different fluorometric methods used to determine free erythrocyte protoporphyrin (FEP) blood concentration. The first method is based on an extractive procedure, whereas the second one involves the direct fluorometric analysis of whole blood. Our results show that the extractive procedure is probably the most reliable technique available for FEP determination, but it is not so suitable for mass screening, whereas the direct fluorometric determination of FEP blood concentration is probably less reliable, but sufficiently enough to be used for mass screening. We have furthermore investigated whether the FEP test could be used as a unique monitoring method for subclinical lead poisoning. Our findings indicate that FEP test can detect very early metabolic alterations, but it is not so suitable for determining lead absorption and should therefore be used in mass screening together with a dose indicator, such as blood lead concentration.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00378094
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    High-performance liquid chromatography for the quantitative determination of the urinary metabolites of toluene, xylene, and styrene (1982)
    Springer
    International archives of occupational and environmental health 50 (1982), S. 25-31 
    Details
    ISSN: 1432-1246
    Schlagwort(e): Toluene ; Xylene ; Styrene ; Hippuric acid ; m-Methylhippuric acid ; Phenylglyoxylic acid ; Mandelic acid ; Urinary metabolites
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A new high-pressure liquid chromatography (HPLC) method for simultaneous quantitative determination of the urinary metabolites of toluene, m-xylene, and styrene (hippuric acid, m-methylhippuric acid, phenylglyoxylic acid, mandelic acid) is described. The extraction procedure was performed on acidified urines, after addition of 4-hydroxybenzoic acid as internal standard, using a butylchloride/isopropanol mixture and drying 0.5 ml of the organic layer under nitrogen flow. The residue obtained was dissolved in 0.1 ml water/acetonitrile and 5 μl were injected into an HPLC apparatus equipped with a 0.26 × 25 cm HC ODS SIL X column. Absorbance measures were performed at 225 nm throughout the investigation. All metabolites were clearly separated in a short time (12 min) and the amounts of other urinary compounds affecting the analysis were so small that the measurement of low concentrations of the urinary metabolites could be easily performed. Linear calibration curves were obtained from 0.1 to 3 mg/ml and a correlation coefficient greater than 0.99 was found between concentrations of the standards and areas of the peaks. Statistical analysis confirms that this method, which has a high reproducibility, is simple, reliable, and useful for the biologic monitoring of industrial exposure to aromatic compounds.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00432491
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Toxic myopathy induced by industrial minerals oils: Clinical and histopathological features (1986)
    Springer
    Neurological sciences 7 (1986), S. 599-604 
    Details
    ISSN: 1590-3478
    Schlagwort(e): Myopathy ; toxic agents ; mineral oils
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Sommario Viene descritto un caso di miopatia subacuta insorta in un uomo di 47 anni addetto alla manutenzione e pulizia delle caldaie di combustione di una centrale termoelettrica. L'anamnesi lavorativa mette in risalto la rilevanza dell'esposizione all'inalazione delle ceneri, derivate dalla combustione di oli minerali e contenenti vari elementi, metalli e metalloidi, tra cui in particolare vanadio e nichel. La sintomatologia d'esordio, il decorso clinico ed i dati istopatologici muscolari suggeriscono come l'esposizione al tossico abbia una verosimile importanza nella determinazione del quadro.
    Notizen: Abstract We report a case of subacute myopathy in a 47 years old man engaged on boiler maintenance at an oil-fired thermoelectric power station. The occupational history highlighted heavy exposure to inhalation of ash derived from mineral oil combustion and containing several elements, metals and metalloids, including vanadium and nickel. The presenting symptoms, clinical course and muscle histopathology suggest that exposure to toxic agents probably played an important part in the causation of the myopathy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02341474
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
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