Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Effects of foreign bodies on development of urinary bladder tumors in rats treated with N-butyl-N-(4-hydroxybutyl) nitrosamine (1973)
    Springer
    Urological research 1 (1973), S. 177-181 
    Details
    ISSN: 1434-0879
    Keywords: Rat urinary bladder cancer ; promoting effect ; foreign bodies ; N-butyl-N-(4-hydroxybutyl) nitrosamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of chronic mechanical stimulation induced by glass balls or paraffin balls on precursor lesions of the urinary bladder of male Wistar strain rats induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in the drinking water were studied. When foreign bodies were present in the bladder, proliferative lesions of the urinary bladder epithelium were found even without administration of carcinogen. When the foreign bodies were implanted into the urinary bladder and then rats were given BBN in the drinking water for the first 4 weeks of the experimental period, a high incidence of tumors of the urinary bladder was observed. The incidence of tumors induced by BBN was increased by the presence of glass balls or paraffin balls in the urinary bladder. These results clearly show that foreign bodies in the urinary bladder have a significant effect in promoting carcinogenesis of the urinary bladder in rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00256620
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Effects of single chemotherapeutic agents on development of urinary bladder tumor induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in rats (1987)
    Springer
    Urological research 15 (1987), S. 329-334 
    Details
    ISSN: 1434-0879
    Keywords: Chemotherapy ; Rat urinary bladder tumor ; N-butyl-N-(4-hydroxybutyl) nitrosamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Chemotherapeutic agents were evaluated for effect on the development of urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in male Wistar strain rats. Seven hundred and two rats were given 0.05% BBN in drinking water for 8 weeks. After BBN treatment, the animals were divided into 26 groups to follow regimens of single chemotherapy. All drugs were administered intraperitoneally except in one group that was treated orally. In our experimental series, 5-fluorouracil (5-FU), N-(2-tetrahydrofuryl)-5-fluorouracil (FT-207), carbazilquinone (CQ), vincristine (VCR) and cis-diamminedichloroplatinum (CDDP) were effective in inhibiting the incidence of bladder tumor, however, adriamycin (ADM), mitomycin C (MMC), neocarsinostatin (NCS), cyclophosphamide (CPM) and bleomycin (BLM) were not effective.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00265661
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Rat urinary bladder carcinomas induced by N-butyl-N-(4-hydroxybutyl)-nitrosamine and N-methyl-N-nitrosourea (1990)
    Springer
    Urological research 18 (1990), S. 323-326 
    Details
    ISSN: 1434-0879
    Keywords: N-butyl-N-(4-hydroxybuty)nitrosamine ; N-Methyl-N-nitrosourea ; Rat bladder carcinogenesis ; Papillary carcinoma ; Non-papillary carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The present investigation was conducted to examine the combination effect of N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) and N-methyl-N-nitrosourea(MNU) in rat urinary bladder carcinogenesis. Experiment 1 was performed in the groups treated by oral BBN administration in combination with MNU intraversical instillation and their control groups. In the groups given both BBN and MNU, the ratio of rats with the nonpapillary type to carcinoma-bearing rats was significantly higher than in the controls. Since most of the carcinomas were non-invasive, the observation period was prolonged in the groups given both BBN and MNU in experiment 2. However, even after a longer observation period, no invasive carcinoma was observed. These results suggest that high-grade and invasive carcinomas similar to those induced by BBN and MNU in the heterotopically transplanted rat bladder cannot be induced in the natural bladder of the rat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00300780
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...