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  • 1
    Electronic Resource
    Electronic Resource
    Effects of foreign bodies on development of urinary bladder tumors in rats treated with N-butyl-N-(4-hydroxybutyl) nitrosamine (1973)
    Springer
    Urological research 1 (1973), S. 177-181 
    Details
    ISSN: 1434-0879
    Keywords: Rat urinary bladder cancer ; promoting effect ; foreign bodies ; N-butyl-N-(4-hydroxybutyl) nitrosamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of chronic mechanical stimulation induced by glass balls or paraffin balls on precursor lesions of the urinary bladder of male Wistar strain rats induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in the drinking water were studied. When foreign bodies were present in the bladder, proliferative lesions of the urinary bladder epithelium were found even without administration of carcinogen. When the foreign bodies were implanted into the urinary bladder and then rats were given BBN in the drinking water for the first 4 weeks of the experimental period, a high incidence of tumors of the urinary bladder was observed. The incidence of tumors induced by BBN was increased by the presence of glass balls or paraffin balls in the urinary bladder. These results clearly show that foreign bodies in the urinary bladder have a significant effect in promoting carcinogenesis of the urinary bladder in rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00256620
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of single chemotherapeutic agents on development of urinary bladder tumor induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in rats (1987)
    Springer
    Urological research 15 (1987), S. 329-334 
    Details
    ISSN: 1434-0879
    Keywords: Chemotherapy ; Rat urinary bladder tumor ; N-butyl-N-(4-hydroxybutyl) nitrosamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Chemotherapeutic agents were evaluated for effect on the development of urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in male Wistar strain rats. Seven hundred and two rats were given 0.05% BBN in drinking water for 8 weeks. After BBN treatment, the animals were divided into 26 groups to follow regimens of single chemotherapy. All drugs were administered intraperitoneally except in one group that was treated orally. In our experimental series, 5-fluorouracil (5-FU), N-(2-tetrahydrofuryl)-5-fluorouracil (FT-207), carbazilquinone (CQ), vincristine (VCR) and cis-diamminedichloroplatinum (CDDP) were effective in inhibiting the incidence of bladder tumor, however, adriamycin (ADM), mitomycin C (MMC), neocarsinostatin (NCS), cyclophosphamide (CPM) and bleomycin (BLM) were not effective.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00265661
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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