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Digitale Medien

NMDA receptor antagonists reduce medial, but not lateral, perforant path-evoked EPSPs in dentate gyrus of rat hippocampal slice (1990)

Dahl, D. ; Burgard, E. C. ; Sarvey, J. M.

Springer

Experimental brain research 83 (1990), S. 172-177

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Details

ISSN: 1432-1106

Schlagwort(e): Synaptic transmission ; Excitatory amino acids ; NMDA receptor antagonists ; Hippocampal formation ; Long-term potentiation ; Rat

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary NMDA receptor antagonists produced differential effects on medial and lateral perforant path-evoked excitatory postsynaptic potentials (EPSPs) recorded in the dentate gyrus molecular layer of hippocampal slices. D-(-)-2-amino-5-phosphonovaleric acid (D(-)APV) and 3-[(±)-2-carboxypiperazin-4-yl]-propyl-1-phosphonic acid (CPP) significantly reduced the peak amplitude and total area, but not the initial negative slope, of the medial perforant path-evoked EPSP. Neither antagonist affected any component of the lateral perforant path-evoked EPSP. In contrast, population spikes evoked by stimulation of either pathway were depressed.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00232206

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