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  • 1990-1994  (2)
  • 27.70.+ q  (1)
  • Naltrexone  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 111 (1993), S. 215-218 
    ISSN: 1432-2072
    Keywords: Self-administration ; Progressive ratio ; Heroin ; Dose-response ; Naltrexone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Heroin self-administration behavior under a progressive ratio (PR) schedule of reinforcement was evaluated in rats. The schedule was designed to restrict drug intake, minimize opiate dependency, and quantify the number of responses emitted (final response ratio) in order to receive a limited number of heroin infusions. Final ratios were found to be stable and did not increase with chronic (31 days) PR reinforcement. The ability of the PR schedule to detect changes in heroin reinforcement was demonstrated by evaluating the effect of naltrexone pretreatment and unit dose alteration on final ratios. Naltrexone (0.4 mg/kg) reduced final ratios and an inverted U dose-response relationship was established for the unit heroin doses 12.5–100 µg/injection. Maximal final ratios occurred with 50 µg/injection heroin reinforcement. This PR schedule may provide a useful method for evaluating the effects of pharmacological manipulations or lesions on opiate reinforcement.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1434-601X
    Keywords: 23.90.+ w ; 23.90.+ e ; 27.70.+ q
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The fusion reaction74Se+106Cd→180Pb* at a compound nucleus excitation energy Ex ≃ 40 MeV, has been used in a search for the decay of the unknown nucleus177Tl. Evaporation residues were velocity and mass analysed prior to implantation into a position sensitive silicon surface barrier detector. No evidence was discovered for the proton or alpha-decay of177Tl for a cross-section 〉 10 − 5+10 nb. This indicates either that177Tl decays too rapidly (t1/2 〈 1 μs) by proton emission for the decay to be detected, or that177Tl is produced with a cross-section less than the limit established in the present experiment. The following nuclear decay half-lives were measured with improved accuracy;177Hg (t1/2 = 130±5 ms),178Hg (t1/2=250±25 ms) and177Au (t1/2=1180±70 ms). The experiment also provided the first direct confirmation of the correct mass assignment of the alpha-decay, Eα=6.26 MeV, to the decay of176Au. Two additional halflife measurements of proton-rich Osmium isotopes are also presented from a previous similar experiment;165Os (t1/2=73±8 ms) and166Os (t1/2 = 194±17 ms).
    Type of Medium: Electronic Resource
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