ISSN:
1432-198X
Keywords:
Tobramycin
;
Cefotaxim
;
Nephrotoxicity
;
Adenosine deaminase binding protein
;
Neonates
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The potential tubulotoxicity of tobramycin and cefotaxim were assessed in neonates by measuring the urinary level of adenosine deaminase binding protein (ABP) and urinary α1-microglobulin and β2-microglobulin. In a prospective study, 33 neonates who received tobramycin and cefotaxim for suspected neonatal sepsis were compared with 48 untreated newborns during the first 10 days of life. The urinary concentrations of ABP and its excretion rates, corrected for body weight and body surface area, were significantly increased from the 1st day of treatment. Urinary α1-microglobulin and β2-microglobulin were not elevated under tobramycin and cefotaxim during the first 2 days of treatment. We conclude that ABP may be a sensitive marker for the detection of proximal renal tubular injury during tobramycin and cefotaxim treatments of neonates. The increase in urinary ABP which occurs before an elevation of urinary α1-microglobulin and β2-microglobulin may reflect earlier structural than functional alterations. However, since none of the treated infants had signs of electrolyte disorders or glomerular dysfunction, the clinical relevance of ABP measurement should be reevaluated.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00866714
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