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  • Cell & Developmental Biology  (3)
  • Neoplasms  (3)
  • 1
    ISSN: 1432-1084
    Schlagwort(e): MR ; Perfusion study ; Brain ; Necrosis ; Edema ; Neoplasms
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The aim of this study was to characterize intracranial tumors based on MR measurements of regional cerebral blood volume. In 8 patients without intracranial pathology and 42 patients with intracranial tumors a T2*-weighted image series was acquired during bolus injection of gadolinium-DTPA, and regional cerebral blood volume maps were calculated. The regional cerebral blood volume index (rCBVi) of vital tumor was expressed in percent of the value measured in contralateral gray matter. In extra-axial tumors (meningiomas) rCBVi was higher (124 ± 110%), and in low-grade intra axial tumors rCBVi was lower (79 ± 65%), than in contralateral cortex. In malignant intra-axial tumors the distribution of rCBV was heterogenous: high in vital tumor (glioblastomas: rCBVi = 165 ± 85%; metastases: rCBVi = 106 ± 79%), but low in necrosis (rCBVi = 33% of contralateral white matter) and edema (rCBVi = 53% of contralateral white matter). rCBVi was highest in arteriovenous malformations (1053 ± 584% of contralateral gray matter). We conclude that the regional cerebral blood volume distribution is useful to characterize intracranial tumors, although the large biological variability of individual tumor entities indicates limitations.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    ISSN: 1432-1084
    Schlagwort(e): Key words: MR ; Surface coils ; Pulse sequences ; Eye ; Neoplasms
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract. To develop an improved investigation protocol for MRI studies of intraocular lesions, imaging with a small surface coil (diameter 6 cm) was compared with a standard surface coil (diameter 11 cm). Both coils were assessed initially on an eye phantom and then by studying 22 patients with uveal melanoma and similar lesions of the eye. The influence of bandwidth and field or view (FOV) were systematically studied and evaluated quantitatively. A smaller bandwidth improved image quality independent of surface coil size. The subsequent secondary increase in chemical shift artefact was acceptable. Smaller FOVs (60–80 mm) necessitated the use of a smaller surface coil. A smaller bandwidth also proved to be advantageous with the use of the smaller surface coil. In conclusion, a smaller-diameter surface coil improves MR imaging of ocular lesions. Pulse sequences with a small bandwidth maintain an acceptable signal-to-noise ratio when the FOV is reduced.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Springer
    European radiology 9 (1999), S. 428-435 
    ISSN: 1432-1084
    Schlagwort(e): Key words: Liver ; Neoplasms ; Ultrasound ; Doppler studies ; Contrast media
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract. Echo patterns of focal liver lesions as well as other morphological criteria do not suffice for differential diagnosis. In an attempt to increase the specificity of ultrasound of focal liver lesions, several years of Doppler-flow information was evaluated. Recent advances in ultrasound technology (power Doppler imaging, second harmonic imaging) as well as commercial availability of an intravenous signal enhancer (contrast agent) have additionally improved results of this technique.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 26 (1923), S. 121-128 
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Zusätzliches Material: 4 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 33 (1926), S. 121-135 
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 6
    Digitale Medien
    Digitale Medien
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 70 (1998), S. 596-603 
    ISSN: 0730-2312
    Schlagwort(e): poly(ADP-ribose) ; PARP ; nuclear matrix ; noncovalent interactions ; Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Recent evidence suggests that poly(ADP-ribose) may take part in DNA strand break signalling due to its ability to interact with and affect the function of specific target proteins. Using a poly(ADP-ribose) blot assay, we have found that several nuclear matrix proteins from human and murine cells bind ADP-ribose polymers with high affinity. The binding was observed regardless of the procedure used to isolate nuclear matrices, and it proved resistant to high salt concentrations. In murine lymphoma LY-cell cultures, the spontaneous appearance of radiosensitive LY-S sublines was associated with a loss of poly(ADP-ribose)-binding of several nuclear matrix proteins. Because of the importance of the nuclear matrix in DNA processing reactions, the targeting of matrix proteins could be an important aspect of DNA damage signalling via the poly ADP-ribosylation system. J. Cell. Biochem. 70:596-603. © 1998 Wiley-Liss, Inc.
    Zusätzliches Material: 4 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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