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  • 1
    Electronic Resource
    Electronic Resource
    Cerebral gangliocytoma (1987)
    Springer
    Acta neuropathologica 74 (1987), S. 169-178 
    Details
    ISSN: 1432-0533
    Keywords: Cerebral gangliocytoma ; Parieto-frontal lobe ; Intracytoplasmic inclusion bodies ; No synapse ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report a case of cerebral gangliocytoma (GC) with a variety of unusual structures in the tumor cells. Light microscopically, the tumor consisted of typical ganglion cells, atypical cells which has argyrophilic granules in the cytoplasm, and a few astrocytes. Electron microscopically, the tumor cells showed typical gangliocytic features, which had abundant rough endoplasmic reticula, ribosomes and cored vesicles of 90–150 nm diameter, a few 50-nm-diametered non-cored vesicles, and other common organelles in their cytoplasm. Furthermore, neoplastic ganglion cells contained a variety of abnormal structures, including membranous cytoplasmic bodies (MCB), Zebra bodies (ZB), tubular structures, branched tubular structures (BTS), concentrical laminated bodies and curvilinear bodies (CB). The MCB, ZB and CB resembled those in GM2 gangliosidosis (GMG), and the BTS that in infantile neuroaxonal dystrophy (INAD). Although the significance of these inclusions is still unknown, it is considered that some common mechanism might play a role in the metabolism of both neoplastic neuronal cells and degenerating neurons (GMG and INAD). Synapses could not be observed anywhere despite complete neuronal differentiation of many tumor cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00692848
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  • 2
    Electronic Resource
    Electronic Resource
    An autopsy case of peroneal muscular atrophy with rigidity and tremor (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 671-679 
    Details
    ISSN: 1432-0533
    Keywords: Peroneal muscular atrophy ; Rigidity and tremor ; Autopsy ; Morphometry ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An autopsy case of hereditary peroneal muscular atrophy (PMA) with rigidity and static tremor is presented. The patient developed slowly progressive distal muscular atrophy of the legs at the age of 15 years. By the age of 52 years, PMA became marked associated with pes cavus, and tremor and rigidity of the extremities were noted. Motor and sensory conduction velocities gradually depressed and lost near the end of his life. At autopsy, the major neuropathological abnormalities involved the peripheral nervous systems, and were characterized by axonal atrophy and loss of myelinated fibres. These changes involved both the proximal and distal nerves, being more severely affected in the distal. The pathological changes in other regions of the nervous systems were mainly confined to the spinal cord, dorsal ganglia and spinal nerve roots, and pigmented neurons in the brain stem. Morphometrically, the total fascicular area was much smaller than in control, but the total number of myelinated fibers greatly outnumbered that of control 75 200 to 48 200 at the proximal sciatic nerve and then gradually decreased towards the periphery; however, even in the distal sural nerve, the total number of myelinated fibers exceeded that of control (6820 to 5469). Thus, the density of myelinated fibers were much higher, being 1.5 to 2 times greater, than in control. Its abrupt decline at the distal nerve might account for neurogenic atrophy of the distal musculature. Unmyelinated fibers were slightly increased in density and not atrophic. This case is unique in its clinicopathology and does not belong to any subtypes of PMA including “neuronal plus”.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00307638
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  • 3
    Electronic Resource
    Electronic Resource
    Target-targetoid phenomenon of the human muscle fibers (1977)
    Springer
    Virchows Archiv 375 (1977), S. 13-22 
    Details
    ISSN: 1432-2307
    Keywords: Target-targetoid phenomenon ; Histochemistry ; Electron microscopy ; Z-band alteration ; Incomplete innervation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Target and targetoid fibers in a muscle biopsy from a patient with paralysis of the deltoid and supraspinatus muscles were studied by light and electron microscopy. The probable cause of the neuropathy was tumor compression. Target and targetoid change was exclusively confined to hypertrophic or normal-sized fibers. Morphometric evaluation of the target and targetoid fibers showed no significant difference between them. With the electron microscope, up to 4 structural zones were seen in the typical target fiber but many were devoid of either zone 2 (halo) or zone 3, or both. It was conceivable that focal irregularity and streaming of Z-bands were the primary alterations in the process of target-targetoid fiber formation, and that this phenomenon was induced both by partial residual innervation as well as re-innervation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00430641
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  • 4
    Electronic Resource
    Electronic Resource
    Scanning electron microscopical study of the neurofibrillary tangles of Alzheimer’s disease (1997)
    Springer
    Acta neuropathologica 94 (1997), S. 78-86 
    Details
    ISSN: 1432-0533
    Keywords: Key words Paired helical filament ; Neurofibrillary ; tangles ; Scanning electron microscopy ; Alzheimer’s ; disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Neurofibrillary tangles (NFTs) have been ultrastructually studied by various methods, leading to several three-dimensional models of paired helical filaments (PHFs). In this study, we present the scanning electron microscopic findings of NFTs in an autopsy case of Alzheimer’s disease and clarify the three-dimensional structures of NFTs. NFTs were clearly defined in freeze-cracked nerve cells and consisted of two types of filamentous structures, straight and helical filaments. Straight filaments measured from 20 to 25 nm in diameter and had a smooth surface. They were slightly bent but mostly straight with no constrictions. One type of straight filaments ran in a bundle in the same direction, another was intertwined to each other. Most of the helical profiles of filaments usually measured about 28 nm in diameter, with a distance of 100 nm between periodic constrictions. They seemed to consist of a pair of isodiametric filaments of 10 nm in diameter. In addition, two unusual types of helical filaments were occasionally observed. One comprised thick filaments of about 38 nm in diameter, with a distance of 100 nm between constrictions; these helical filaments appeared to consist of two or more strands. The other comprised thin helical filaments of about 20 nm in diameter and regularly constricted at an interval of 50 nm. All types of the helical filaments examined in this case were leotropic. This result supports a protofilament model of PHFs. Scanning electron microscopy using the freeze-cracked and maceration method is a useful and simple method for three-dimensional observation of the filamentous structures in NFTs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010050675
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  • 5
    Electronic Resource
    Electronic Resource
    Scanning electron microscopical study of neurofibrillary tangles in a presenile patient with Down’s syndrome (1998)
    Springer
    Acta neuropathologica 96 (1998), S. 179-184 
    Details
    ISSN: 1432-0533
    Keywords: Key words Paired helical filaments ; Neurofibrillary ; tangles ; Down’s syndrome ; Alzheimer’s disease ; Scanning electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An autopsy case of a 64-year old woman with Down’s syndrome (DS) is reported with a special reference to the ultrastructure of neurofibrillary tangles (NFTs). NFTs and senile plaques were diffusely observed throughout the brain. The most severe changes were seen in the amygdaloid nuclear complex and hippocampus. Immunohistochemistry of the NFTs and senile plaques indicated the features identical to those in Alzheimer’s disease (AD). Ultrastructurally, NFTs were composed of straight filaments and two profiles of paired helical filaments (PHFs). By transmission electron microscopy, straight filaments measured 25–28 nm in diameter. As to the PHFs, one type was 33 nm in maximum diameter and constricted at a 75– to 80-nm interval. The other was 16–18 nm in maximum diameter and constricted at a 35– to 40-nm interval. By scanning electron microscopy, the diameter of the straight filaments measured up to 28–30 nm. Two profiles of PHFs were observed. One type of PHF showed thick filaments about 34 nm in maximum diameter and constrictions at an 80-nm interval. The other was about 17 nm in diameter and constricted at a 40-nm interval. The helical directions of both PHFs were left-handed. The frequency of PHFs with short interval was much higher in DS than AD. Furthermore, the length of the periodicity of this type of PHF was somewhat less than that of AD. Thus, these findings suggest that the neuropathological changes in DS and AD share a common etiopathology, but that some differences in the PHFs between DS and AD may reflect on molecular difference in the proteins or peptides associated with PHF formation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010050879
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  • 6
    Electronic Resource
    Electronic Resource
    Cerebral neuroblastoma (1978)
    Springer
    Virchows Archiv 381 (1978), S. 1-11 
    Details
    ISSN: 1432-2307
    Keywords: Central neuroblastoma ; Electron microscopy ; Growth cone ; Primitive neural crest ; Neuronal cytogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A cerebral neuroblastoma removed surgically from a female child is presented. Electron microscopy showed numerous neuronal processes with growth cones which are a feature of the developing neurone. In addition there were some rosettes with distinct lumina. The luminal surfaces were covered with a smooth plasma membrane lacking any surface differentiation and the lateral surface of these cells had many cell junctions (terminal bars), reminiscent of a primitive neural tube. These features in a nerve cell tumor help to substantiate it as a neuroblastoma arising from immature rather than differentiated cells. The nature of this rare tumor is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00433481
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